FB2026_02 , released June 18, 2026
Allele: Dmel\exexAD121
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General Information
Symbol
Dmel\exexAD121
Species
D. melanogaster
Name
FlyBase ID
FBal0137271
Feature type
allele
Associated gene
Dmel\exex
Associated Insertion(s)
Carried in Construct
Also Known As
hb9ad121
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Broihier and Skeath, 2002)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1003T.

(Broihier and Skeath, 2002)

Amino acid replacement: A?term.

(Broihier and Skeath, 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,949,174..7,949,174 [+]
Nucleotide change:

C7949174T

Reported nucleotide change:

C1003T

Amino acid change:

A270V | exex-PA

Reported amino acid change:

A270term

Comment:

The mutation is reported as C to T base change leading to a nonsense mutation in Ala 270, however a C to T base change in that codon leads to a Ala to Val amino acid change.

(Broihier and Skeath, 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      FlyBase curator comment: Authors state that this is a nonsense mutation - C1003T. However Figure 1D indicates mutation maps to an Ala, even though a C to T change in an Ala cannot generate a stop codon.

      (Broihier and Skeath, 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dHb9AD121
      (Broihier and Skeath, 2002)
      exexAD121
      hb9ad121
      (Santiago and Bashaw, 2017, Santiago et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)