FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MicalUAS.cTa
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General Information
Symbol
Dmel\MicalUAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Terman
FlyBase ID
FBal0137462
Feature type
allele
Associated gene
Dmel\Mical
Associated Insertion(s)
Carried in Construct
P{UAS-MICAL.T}
Also Known As
UAS-mical
Key Links
Transgenic product class
wild_type
(Terman et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Terman et al., 2002)
Mutagen
in vitro construct
(Terman et al., 2002, Terman et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-MICAL.T}
Cytology
Description

UAS regulatory sequences drive expression of the Mical short isoform.

(Terman et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mical
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MICALScer\UAS.cTa under the control of Scer\GAL4elav.PLu results in 44.2% of hemisegments having defects in muscle 6/7 innervation (in 59.6% of these cases they show increased muscle innervation, excessive branching or projection into abnormal target fields) and 50.0% having defects in muscle 12/13 innervation. 38.0% of hemisegments show SNa pathway defects (in 71.4% of these cases they show fasciculation with the ISN, premature branching, follow abnormal pathways or terminate on the wrong muscle).

      (Terman et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      MicalUAS.cTa/Scer\GAL4elav.PLu partially rescues Df(3R)swp2MICAL

      (Terman et al., 2002)
      Fails to rescue

      MicalUAS.cTa/Scer\GAL4how-24B fails to rescue Micalunspecified

      (Beuchle et al., 2007)

      MicalUAS.cTa/Scer\GAL4elav.PLu fails to rescue Micalunspecified

      (Beuchle et al., 2007)
      Comments

      Expression of MicalScer\UAS.cTa under the control of one of Scer\GAL4how-24B or Scer\GAL4elav.PLu does not substantially rescue the synaptic or flightless phenotypes of Micalunspecified mutants.

      (Beuchle et al., 2007)

      Expression of MICALScer\UAS.cTa under the control of Scer\GAL4elav.PLu does not rescue the lethality of Df(3R)swp2MICAL homozygotes, although the embryonic ISNb and SNa axon guidance defects are almost completely rescued.

      (Terman et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      MICALScer\UAS.cTa
      MicalScer\UAS.cTa
      MicalUAS.cTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Terman
      (Terman et al., 2002)
      Secondary FlyBase IDs
        References (6)