FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spzact.UAS
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General Information
Symbol
Dmel\spzact.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0138129
Feature type
allele
Associated gene
Dmel\spz
Associated Insertion(s)
Carried in Construct
P{UAS-spz.act}
Also Known As
UAS-SpzAct, UAS-spz*, UAS-spz
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ligoxygakis et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-spz.act}
Cytology
Description

UAS regulatory sequences drive expression of a cleaved (activated) form of spz.

(Ligoxygakis et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
spz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by Ras85DV12.UAS, l(2)gl4
      (Mishra-Gorur et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Expression of spzact.UAS induces metastasis of Ras85DV12.UAS l(2)gl4-induced tumors.

      (Mishra-Gorur et al., 2019)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4elav-C155/spzact.UAS is a suppressor of increased cell death phenotype of NT141

      (Zhu et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of spzact.Scer\UAS in NT141 mutant embryos partially rescues apoptosis levels, but does not rescue the NT141 mutant phenotype.

      (Zhu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spzact.Scer\UAS
      spzact.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (18)