FlyBase Allele Report: Dmel\sav[GMR.PT]

General Information

Symbol

Dmel\sav^GMR.PT

Species

D. melanogaster

Name

glass multimer reporter construct of Tapon

FlyBase ID

FBal0138133

Feature type

allele

Associated gene

Dmel\sav

Associated Insertion(s)

Carried in Construct

P{GMR-sav.T}

Also Known As

GMR-sav

Key Links

Transgenic product class

wild_type

(Tapon et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tapon et al., 2002)

Mutagen

in vitro construct

(Tapon et al., 2002)

Progenitor genotype

Carried in construct

P{GMR-sav.T}

Cytology

Description

GMR regulatory sequences drive expression of sav.

(Tapon et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

sav

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has abnormal size | adult stage phenotype, enhanceable by Tao^{UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

sav^GMR.PT, wts^GMR.PT has visible | adult stage phenotype, enhanceable by Tao^{UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

NOT Enhanced by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has abnormal size | adult stage phenotype, non-enhanceable by Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

sav^GMR.PT, wts^GMR.PT has visible | adult stage phenotype, non-enhanceable by Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

Suppressed by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has abnormal neuroanatomy | adult stage phenotype, suppressible | somatic clone by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

Suppressor of

Statement

Reference

sav^GMR.PT/wts^GMR.PT is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

NOT Suppressor of

Statement

Reference

sav^GMR.PT is a non-suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, hpo^{N.UAS.Tag:FLAG}

(Jia et al., 2003)

Other

Statement

Reference

sav^GMR.PT, wts^GMR.PT has abnormal neuroanatomy | adult stage phenotype

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has abnormal cell number | adult stage phenotype

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has visible | adult stage phenotype

(Poon et al., 2011)

sav^GMR.PT, wts^GMR.PT has abnormal size | adult stage phenotype

(Poon et al., 2011)

sav^GMR.PT, wts^GMR.PT has increased cell death phenotype

(Pantalacci, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has eye phenotype, enhanceable by Tao^{UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

NOT Enhanced by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has eye phenotype, non-enhanceable by Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF

(Poon et al., 2011)

Suppressed by

Statement

Reference

sav^GMR.PT, wts^GMR.PT has photoreceptor cell R8 of pale ommatidium phenotype, suppressible | somatic clone by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has photoreceptor cell R8 of yellow ommatidium phenotype, suppressible | somatic clone by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has eye phenotype, suppressible by Rassf^UAS.cPa/Scer\GAL4^GMR.PF

(Polesello et al., 2006)

Suppressor of

Statement

Reference

sav^GMR.PT/wts^GMR.PT is a suppressor | partially of photoreceptor cell R8 of pale ommatidium | somatic clone phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

sav^GMR.PT/wts^GMR.PT is a suppressor | partially of photoreceptor cell R8 of yellow ommatidium | somatic clone phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

NOT Suppressor of

Statement

Reference

sav^GMR.PT is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, hpo^{N.UAS.Tag:FLAG}

(Jia et al., 2003)

Other

Statement

Reference

sav^GMR.PT, wts^GMR.PT has photoreceptor cell R8 of yellow ommatidium phenotype

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has photoreceptor cell R8 of pale ommatidium phenotype

(Jukam et al., 2016)

sav^GMR.PT, wts^GMR.PT has eye phenotype

(Poon et al., 2011, Polesello et al., 2006, Harvey et al., 2003)

sav^GMR.PT, wts^GMR.PT has ommatidium phenotype

(Harvey et al., 2003)

sav^GMR.PT, wts^GMR.PT has eye disc | larval stage phenotype

(Pantalacci, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with sav^GMR.PT and wts^GMR.PT have a dramatically increased proportion of yellow R8 photoreceptors and a reciprocally decreased proportion of pale R8 photoreceptors; this is suppressed in clones that are also homozygous for BEAF-32^AB-KO, to the extent that the proportion of yellow R8 photoreceptors is decreased compared to wild-type controls.

(Jukam et al., 2016)

Co-expression of wts^GMR.PT and sav^GMR.PT results in a decrease in eye size.

Expression of Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PF enhances the decrease in eye size seen when wts^GMR.PT and sav^GMR.PT are co-expressed.

Expression of Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PF is unable to enhance the decrease in eye size seen when wts^GMR.PT and sav^GMR.PT are co-expressed.

(Poon et al., 2011)

Expression of sav^GMR.PT and wts^GMR.PT together at 28^oC induces a mild reduction in eye size and roughness. Eye clones of ft⁸ misexpressing sav^GMR.PT and wts^GMR.PT together at 28^oC exhibit small eyes, indicating that the small-eye phenotype produced by misexpressing sav^GMR.PT and wts^GMR.PT together is epistatic to the eye size resulting from ft⁸.

(Bennett and Harvey, 2006)

Coexpression of sav^GMR.PT and wts^GMR.PT results in a rough eye phenotype.

Expression of Rassf^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF inhibits the rough eye phenotype generated by coexpression of sav^GMR.PT and wts^GMR.PT.

(Polesello et al., 2006)

sav^GMR.PT; wts^GMR.PT flies have small rough eyes. This phenotype is suppressed when somatic clones of hpo^MGH1 homozygous cells are generated throughout the eye discs using Scer\FLP1^ey.PN with P{neoFRT}42D.

(Harvey et al., 2003)

Co-expression of sav^GMR.PT and wts^GMR.PT posterior to the morphogenetic furrow in the imaginal eye disc induces apoptosis.

Levels of apoptosis induced by co-expression of sav^GMR.PT and wts^GMR.PT posterior to the morphogenetic furrow in the imaginal eye disc is not affected in Df(2L)flp170B mutant clones.

Co-expression of sav^GMR.PT and wts^GMR.PT posterior to the morphogenetic furrow in the imaginal eye disc induces apoptosis. Levels of apoptosis induced by co-expression of sav^GMR.PT and wts^GMR.PT posterior to the morphogenetic furrow in the imaginal eye disc is not affected in bsk² mutant clones.

(Pantalacci, 2003)

The rough eye phenotype due to hpo^GMR.PW is enhanced by sav^GMR.PT.

(Wu et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sav^GMR.PT

Name Synonyms

glass multimer reporter construct of Tapon

(Tapon et al., 2002)

Secondary FlyBase IDs

References (12)

Report Sections

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