FlyBase Allele Report: Dmel\Tao[D168A.UASp.Tag:FLAG]

General Information

Symbol

Dmel\Tao^{D168A.UASp.Tag:FLAG}

Species

D. melanogaster

Name

FlyBase ID

FBal0265574

Feature type

allele

Associated gene

Dmel\Tao

Associated Insertion(s)

Carried in Construct

P{UASp-Tao.D168A.FLAG}

Key Links

Transgenic product class

missense_variant

(Sato et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Sato et al., 2007)

Mutagen

in vitro construct

(Sato et al., 2007)

Progenitor genotype

Carried in construct

P{UASp-Tao.D168A.FLAG}

Cytology

Description

UASp regulatory sequences drive expression of a mutant form or Tao in which the aspartate at residue 168 has been replaced by an alanine. The construct is tagged with Tag:FLAG.

(Sato et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Tao

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile, with Scer\GAL4^{VP16.nanos.UTR}

(Sato et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

The wings of flies expressing Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} under the control of Scer\GAL4^hh.PU are a similar size to controls.

Expression of Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PF is unable to enhance the decrease in eye size seen when wts^GMR.PT and sav^GMR.PT are co-expressed.

(Poon et al., 2011)

The amount of pole cell apoptosis seen when Tao-1^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} is comparable to controls.

(Sato et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of abnormal size | adult stage phenotype of sav^GMR.PT, wts^GMR.PT

(Poon et al., 2011)

Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of visible | adult stage phenotype of sav^GMR.PT, wts^GMR.PT

(Poon et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of increased cell death | maternal effect | embryonic stage 13 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of increased cell death | maternal effect | embryonic stage 14 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of increased cell death | maternal effect | embryonic stage 15 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of increased cell death | maternal effect | embryonic stage 16 phenotype of nanos^BN

(Sato et al., 2007)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Tao^{D168A.UASp.Tag:FLAG}/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of sav^GMR.PT, wts^GMR.PT

(Poon et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of primordial germ cell | maternal effect | embryonic stage 13 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of primordial germ cell | maternal effect | embryonic stage 14 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of primordial germ cell | maternal effect | embryonic stage 15 phenotype of nanos^BN

(Sato et al., 2007)

Scer\GAL4^{VP16.nanos.UTR}/Tao^{D168A.UASp.Tag:FLAG} is a suppressor of primordial germ cell | maternal effect | embryonic stage 16 phenotype of nanos^BN

(Sato et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Tao-1^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} suppresses the pole cell apoptosis seen in stage 13-16 embryos derived from nos^BN females.

(Sato et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tao-1^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}

Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG}

Tao^{D168A.UASp.Tag:FLAG}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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