FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ScrScx
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General Information
Symbol
Dmel\ScrScx
Species
D. melanogaster
Name
FlyBase ID
FBal0138396
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
?{}AntpScx
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    ?{}AntpScx
    Cytology
    Description

    Four genetic properties are associated with the "Scx" chromosome (which has an insertion of repetitive DNA very close to the Antp P1 promoter); loss of Antp P1 promoter function, loss of Antp P2 promoter function, derepression of the Scr promoter in cis (on the mutant chromosome) and derepression of the Scr promoter in trans (on the homologous chromosome). The ectopic sex comb teeth on the second and third legs seen in "Scx" heterozygotes are due to misexpression of Scr in cis and in trans.

    (Southworth and Kennison, 2002)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygous males have an average of 2.7 ectopic sex comb teeth per second leg. The number of sex comb teeth on the first leg is normal. ScrScx/Scr4 males have the same average number of sex comb teeth per first leg as Scr4/+ males. Heterozygous males have an average of 0.1 ectopic sex comb teeth per third leg. ScrScx/Scr2 males have an average of 1.3 ectopic sex comb teeth per second leg and no ectopic sex comb teeth on the third legs. ScrScx/Scr4 males have an average of 1.6 ectopic sex comb teeth per second leg and an average of 0.1 ectopic sex comb teeth per third leg. ScrScx/Scr4; Dp(3;Y)77ab males have an average of 1.4 ectopic sex comb teeth per second leg and an average of 0.2 ectopic sex comb teeth per third leg. ScrScx/ScrTpl9 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) have an average of 8.7 ectopic sex comb teeth per second leg and an average of 5.0 ectopic sex comb teeth per third leg.

        (Southworth and Kennison, 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        ScrScx/ScrTpl9 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) also carrying Pc21 have an average of 8.5 ectopic sex comb teeth per second leg and an average of 8.4 ectopic sex comb teeth per third leg.

        (Southworth and Kennison, 2002)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ScrScx
        Name Synonyms
        Secondary FlyBase IDs
          References (1)