FB2026_02 , released June 18, 2026
Allele: Dmel\N::MmusNotch1Nmf.lexA.UAS
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General Information
Symbol
Dmel\N::Mmus\Notch1Nmf.lexA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0138463
Feature type
allele
Associated gene
N::Mmus\Notch1
Associated Insertion(s)
Carried in Construct
P{UAS-Nmf.LexA}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kidd and Lieber, 2002)
Progenitor genotype
Carried in construct
P{UAS-Nmf.LexA}
Cytology
Description

UAS regulatory sequences drive expression of a hybrid gene consisting of N in which the furin-dependent cleavage region (amino acids 1593-1744) has been replaced with the corresponding region of Mmus\Notch1 (amino acids 1562-1725). The hybrid protein is also tagged with Ecol\lexA sequence.

(Kidd and Lieber, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
N::Mmus\Notch1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of N::Mmus\Notch1Nmf.Scer\UAS.T:Ecol\lexA under the control of Scer\GAL4da.G32 in a wild-type background results in slight hypertophy of the nervous system in embryos; for example, 2-3 extra cells are found in the dorsal clusters of the peripheral nervous system.

      (Kidd and Lieber, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of N::Mmus\Notch1Nmf.Scer\UAS.T:Ecol\lexA under the control of Scer\GAL4da.G32 rescues the N264-47 neurogenic phenotype.

      (Kidd and Lieber, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      N::Mmus\Notch1Nmf.Scer\UAS.T:Ecol\lexA
      N::Mmus\Notch1Nmf.lexA.UAS
      NmfLexA
      (Kidd and Lieber, 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)