FlyBase Allele Report: Dmel\sgl[UY771]

General Information

Symbol

Dmel\sgl^UY771

Species

D. melanogaster

Name

FlyBase ID

FBal0140938

Feature type

allele

Associated gene

Dmel\sgl

Associated Insertion(s)

P{Mae-UAS.6.11}sgl^UY771

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Monnier et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{Mae-UAS.6.11}sgl^UY771

Cytology

Description

P{Mae-UAS.6.11} insertion 16bp downstream of the transcription start site of sgl, such that overexpression from the P{Mae-UAS.6.11} insertion results in overexpression of sgl.

(Monnier et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{Mae-UAS.6.11}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates galactosemia

modeled by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

chemical resistant, with Scer\GAL4^da.G32

(Monnier et al., 2002)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

NMJ bouton | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

synapse | third instar larval stage, with Scer\GAL4^da.G32

(Jumbo-Lucioni et al., 2014)

Detailed Description

Statement

Reference

Expression of sgl^UY771 under the control of Scer\GAL4^da.G32 results in defective rolling behavior in L3 larvae, with larvae taking significantly more time to roll from inverted to upright, as compared to controls; NMJs of these mutants display synaptic structural over-elaboration, with a significant increase in synaptic bouton number and significant decrease in interbouton distance, as compared to controls.

(Jumbo-Lucioni et al., 2014)

Expression of sgl^UY771 under the control of Scer\GAL4^da.G32 results in increased resistance to hydrogen peroxide compared to wild type.

(Monnier et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sgl^UY771/Scer\GAL4^da.G32 is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

sgl^UY771/Scer\GAL4^da.G32 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

sgl^UY771/Scer\GAL4^da.G32 is a suppressor of NMJ bouton | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

sgl^UY771/Scer\GAL4^da.G32 is a suppressor of synapse | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

sgl^UY771/Scer\GAL4^da.G32 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of sgl^UY771 under the control of Scer\GAL4^da.G32 suppresses the rolling movement defects and the NMJ over-elaboration phenotypes seen in Galt^Δ1AP2/Galt^Δ1AP2 mutant larvae.

(Jumbo-Lucioni et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6767

y¹ w^*; P{Mae-UAS.6.11}sgl^UY771

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sgl^UY771

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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