FlyBase Allele Report: Dmel\pygo[F15]

General Information

Symbol

Dmel\pygo^F15

Species

D. melanogaster

Name

FlyBase ID

FBal0140973

Feature type

allele

Associated gene

Dmel\pygo

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Belenkaya et al., 2002)

Mutagen

ethyl methanesulfonate

(Belenkaya et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q104term.

(Belenkaya et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:31,579,321..31,579,321 [-]

Nucleotide change:

C31579321T

Amino acid change:

Q104term | pygo-PA

Reported amino acid change:

Q104term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Belenkaya et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect | recessive

(Belenkaya et al., 2002)

pair rule phenotype | maternal effect

(Belenkaya et al., 2002)

segment polarity phenotype | maternal effect

(Belenkaya et al., 2002)

some die during embryonic stage | recessive | maternal effect | recessive

(Belenkaya et al., 2002)

Phenotype Manifest In

embryo | maternal effect

(Belenkaya et al., 2002)

embryonic/first instar larval cuticle | maternal effect

(Belenkaya et al., 2002)

ventral denticle belt | maternal effect

(Belenkaya et al., 2002)

Detailed Description

Statement

Reference

Homozygous embryos dervied from homozygous female germline clones die with a strong segment polarity phenotype; the embryos have a "lawn of denticles" phenotype and fail to secrete naked cuticle. Zygotically wild-type embryos dervied from homozygous female germline clones develop a pair-rule phenotype with denticle deletions.

(Belenkaya et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Axn^unspecified pygo^F15 double null embryos have a "lawn of denticles" phenotype resembling the phenotype of pygo^F15 single mutant embryos. Axn^unspecified pygo^F15 double mutant clones in the wing result in wing notching and ectopic wing margin bristles, resembling the phenotype of pygo^F15 single mutant embryos.

(Belenkaya et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pygo^EP1076

(Belenkaya et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pygo^F15

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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