FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ifLOF.m8.UAS
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General Information
Symbol
Dmel\ifLOF.m8.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0141083
Feature type
allele
Associated gene
Dmel\if
Associated Insertion(s)
Carried in Construct
P{UAS-if.LOF.m8}
Key Links
Transgenic product class
missense_variant
(Baker et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Baker et al., 2002)
Mutagen
in vitro construct
(Baker et al., 2002)
Progenitor genotype
ifm8.UAS
(Baker et al., 2002)
Carried in construct
P{UAS-if.LOF.m8}
Cytology
Description

Amino acid replacement: Y222A. Amino acid replacement: Q224A.

(Baker et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
if
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing ifLOF.m8.Scer\UAS under the control of Scer\GAL4337Y rarely show wing blistering at 25o, while more than 50% of these animals show wing blistering at 28o.

      (Baker et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4337Y, ifLOF.m8.UAS has visible | heat sensitive phenotype, enhanceable by mys[+]/mysunspecified

      (Baker et al., 2002)
      Other
      Statement
      Reference

      Scer\GAL4337Y, ifLOF.m8.UAS, mys[+]/mysunspecified has lethal | heat sensitive phenotype

      (Baker et al., 2002)

      Scer\GAL4337Y, ifLOF.m8.UAS, mysunspecified has lethal | heat sensitive phenotype

      (Baker et al., 2002)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4337Y, ifLOF.m8.UAS has wing | heat sensitive phenotype, enhanceable by mys[+]/mysunspecified

      (Baker et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing blistering phenotype caused by expression of ifLOF.m8.Scer\UAS under the control of Scer\GAL4337Y is strongly enhanced by mysunspecified/+.

      (Baker et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ifLOF.m8.Scer\UAS
      ifLOF.m8.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)