FlyBase Allele Report: Dmel\Ilp4[UAS.cIa]

General Information

Symbol

Dmel\Ilp4^UAS.cIa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ikeya

FlyBase ID

FBal0141674

Feature type

allele

Associated gene

Dmel\Ilp4

Associated Insertion(s)

Carried in Construct

P{UAS-Ilp4.I}

Also Known As

UAS-dilp4

Key Links

Transgenic product class

wild_type

(Ikeya et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ikeya et al., 2002)

Mutagen

in vitro construct

(Ikeya et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-Ilp4.I}

Cytology

Description

UASt sequences drive expression of Ilp4.

(Ikeya et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ilp4

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior, with Scer\GAL4^elav-C155

(Wu et al., 2005)

increased body size, with Scer\GAL4^arm.PS

(Ikeya et al., 2002)

increased occurrence of cell division | second instar larval stage, with Scer\GAL4^repo.PU

(Sousa-Nunes et al., 2011)

Phenotype Manifest In

larval neuroblast, with Scer\GAL4^repo.PU

(Sousa-Nunes et al., 2011)

Detailed Description

Statement

Reference

Central nervous system neuroblasts of fed second instar larvae expressing Ilp4^Scer\UAS.cIa under the control of Scer\GAL4^repo.PU show an increase in EdU incorporation compared to controls.

Expression of Ilp4^Scer\UAS.cIa under the control of Scer\GAL4^repo.PU does not affect the body mass of third instar larvae.

(Sousa-Nunes et al., 2011)

Larvae expressing Ilp4^Scer\UAS.cIa, under the control of Scer\GAL4^elav-C155 display a normal feeding response when fed ad libitum. The same third instar larvae fasted for 120 minutes display significantly attenuated feeding rates. Comparison to controls reveal that Ilp4^Scer\UAS.cIa flies (Scer\GAL4^elav-C155) ingest liquid and solid food 33-45% slower.

(Wu et al., 2005)

When Ilp4^Scer\UAS.cIa is driven by Scer\GAL4^arm.PS or Scer\GAL4^Act5C.PP a statistically significant increase in body size is seen.

(Ikeya et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ilp4^Scer\UAS.cHa

Ilp4^Scer\UAS.cIa

Ilp4^UAS.cIa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Ikeya

(Ikeya et al., 2002)

Secondary FlyBase IDs

References (4)

Report Sections

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