Homozygous clones in the eye result in overgrowth.

sav^shrp-1 homozygous mutant clones generated in the male or female germline develop normally. In the testis 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells.

The majority of sav^shrp-1 mutant clones in the eye contain only p type R8 cells.

The heads of flies in which over 90% of the cells for sav^shrp-1 (generated using the "eyFLP" technique) are proportionally larger than other structures, but have a normal overall pattern, including bristles, ocelli and ommatidia. All heads have folded head cuticle and eye tissue. Smaller clones do not produce the cuticle folding phenotype. Homozygous clones in the eye disc show increased spacing between ommatidial clusters. Mutant cells in the eye disc synchronise their cell cycles in the morphogenetic furrow (as occurs in wild type) and progress normally through the second mitotic wave. However, mutant cells still show BrdU incorporation after the second mitotic wave, followed by an extra round of cell division. The extra cell proliferation continues into the pupal stage but ceases 24 hours after pupariation. The extra cell proliferation phenotype is cell autonomous. Mutant pupal retinas contain a significantly increased number of photoreceptor clusters compared to wild type.