FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hrgPAP45
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General Information
Symbol
Dmel\hrgPAP45
Species
D. melanogaster
Name
FlyBase ID
FBal0144242
Feature type
allele
Associated gene
Dmel\hrg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Juge et al., 2002)
Progenitor genotype
hrgk07618
(Juge et al., 2002)
Cytology
Description

Imprecise excision of the P{lacW} insertion from hrgk07618 deletes the first 6 residues of hrg. Most of the 5'-UTR of the longest mRNAs as well as the embryonic transcription start site has also been removed.

(Juge et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants are lethal from late embryonic to second instar larval stages. A slight defect in the head skeleton is seen - the dorsal bridge is distorted.

      (Juge et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      hrgPAP45/hrg[+] is an enhancer of lethal | embryonic stage | maternal effect phenotype of orbmel

      (Benoit et al., 2008)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      hrgPAP45 is an enhancer of ovary phenotype of orbmel

      (Juge et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The percentage of maternal effect embryonic lethality seen in embryos derived from orbmel homozygous females is increased by heterozygosity for hrgPAP45. The percentage of ventralised embryos is increased by heterozygosity for one copy of hrgPAP45.

      (Benoit et al., 2008)

      hrgPAP45/+; orbmel lay almost no eggs. In these females oogenesis stops most frequently at stage 7/8 after which egg chambers degenerate, even though one or two stage 14 oocytes per ovary can be observed.

      (Juge et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      hrgPAP45 is partially rescued by hrg+7.9

      (Juge et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotypic analysis suggests the following allelic series: hrgPAP12 > hrgPAP21 > hrgPAP45.

      (Juge et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hrgPAP45
      (Benoit et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)