FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\domeΔEXT.UAS
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General Information
Symbol
Dmel\domeΔEXT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0144361
Feature type
allele
Associated gene
Dmel\dome
Associated Insertion(s)
Carried in Construct
P{UAS-dome.ΔEXT}
Key Links
Transgenic product class
inframe_deletion
(Ghiglione et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Ghiglione et al., 2002)
Mutagen
in vitro construct
(Ghiglione et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-dome.ΔEXT}
Cytology
Description

UASt regulatory sequences drive expression of dome sequences encoding the 5' UTR and amino acids 1-27 (signal peptide) fused to sequences encoding dome amino acids 873-1281 (transmembrane and intracellular region).

(Ghiglione et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dome
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of domeΔEXT.Scer\UAS in wing discs, driven by Scer\GAL4Bx-MS1096, causes a mild wing phenotype in the adult.

      (Hombria et al., 2005)

      Egg chambers expressing domeΔEXT.Scer\UAS under the control of Scer\GAL4slbo.2.6 lack outer border follicle cells.

      (Ghiglione et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of the domeΔEXT.Scer\UAS transgene with upd1Scer\UAS.T:Avic\GFP-EGFP (both under the control of Scer\GAL4Bx-MS1096) suppresses the reduced wing phenotype seen when upd1Scer\UAS.T:Avic\GFP-EGFP is expressed alone.

      (Hombria et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dome Δext
      (Medioni and Noselli, 2005)
      domeΔEXT.Scer\UAS
      domeΔEXT.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)