FlyBase Allele Report: Dmel\Act5C[3627]

General Information

Symbol

Dmel\Act5C³⁶²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0145240

Feature type

allele

Associated gene

Dmel\Act5C

Associated Insertion(s)

P{lArB}Act5C³⁶²⁷

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Wagner et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{lArB}Act5C³⁶²⁷

Cytology

Description

P{lArB} insertion within a 200bp region approximately 3kb upstream of the Act5C transcriptional start.

(Wagner et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:5,898,310..5,898,458

(Wagner et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Wagner et al., 2002)

some die during larval stage | recessive

(Wagner et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Act5C³⁶²⁷ homozygotes die as first instar larvae. Shortly after hatching the mutant larvae are indistinguishable from wild type with regards to movement, but they soon appear noticeably sluggish and die within 4 days after egg hatching without growing substantially or molting.

(Wagner et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Act5C³⁶²⁷ has lethal | larval stage phenotype, suppressible by Act42A^Act5C.PW

(Wagner et al., 2002)

Phenotype Manifest In