FB2026_02 , released June 18, 2026
Allele: Dmel\toi1
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General Information
Symbol
Dmel\toi1
Species
D. melanogaster
Name
FlyBase ID
FBal0146748
Feature type
allele
Associated gene
toi
Associated Insertion(s)
P{GAL4}toi1
Carried in Construct
Also Known As
D0177
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Dubnau et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{GAL4}toi1
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      toi1 mutants show significantly greater optomotor responsiveness than wild type flies in an optomotor maze paradigm. Optomotor responses in toi1 mutants are significantly decreased when a distraction is present, though not as much as in wild type flies. toi1 optomotor performance is not significantly increased following repeated exposure to the maze.

      Unlike wild type flies, toi1 flies fail to learn to avoid visuals associated with shaking.

      toi1 flies have attenuated baseline brain responses when exposed to visual objects alone, compared to wild type flies. Mutant flies also exhibit an aberrant response to novel objects.

      (van Swinderen et al., 2009)

      Homozygous toi1 mutant flies do not show any change in sensitivity to ethanol vapor compared to controls.

      (Berger et al., 2008)

      In memory tests, mutants perform at 99% of wild-type after a single training session, at 34% after spaced training.

      (Dubnau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      D0177
      (van Swinderen et al., 2009, Berger et al., 2008, Dubnau et al., 2003)
      toi
      (Berger et al., 2008)
      toi1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)