FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rod1100
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General Information
Symbol
Dmel\rod1100
Species
D. melanogaster
Name
FlyBase ID
FBal0146843
Feature type
allele
Associated gene
Dmel\rod
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Savoian et al., 2000)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G2462A.

(Wainman et al., 2012)

Amino acid replacement: ?821term.

(Wainman et al., 2012)

Point mutation.

(Savoian et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,583,874..31,583,874 [+]
Nucleotide change:

T31583874A

Reported nucleotide change:

G2462A

Amino acid change:

L821term | rod-PA

Reported amino acid change:

L821term

Comment:

The mutation is reported as G2462A but there is a T nucleotide at position 2462 relative to the ATG (in codon 821) in the reference sequence. T to A change at this site leads to a nonsense mutation.

(Wainman et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant spermatocytes have a normal number of Golgi structures but their morphology is highly irregular.

      Spermatids from mutant third instar larvae testes do not show cytokinesis defects.

      The acroblast of rod1100 spermatids appears as an aggregate of multiple unfused vesicles in ~half of cases, while it appears as a continuous structure (as in wild type) in the other half.

      (Wainman et al., 2012)

      Chromosome disjunction in mutant spermatocytes is highly asynchronous. During anaphase the dyads either fail to undergo poleward motion, or move polewards at a greatly attenuated rate.

      (Savoian et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mst2 rod1100 double mutant larvae show a higher frequency of ana-telophases in the brain than mst2 single mutants. The ana-telophase figures of the double mutants show chromosome segregation defects that are much more severe than those seen in rod1100 single mutants.

      (Mottier-Pavie et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rod1100
      (Wainman et al., 2012, Mottier-Pavie et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)