FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rhoiks
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General Information
Symbol
Dmel\rhoiks
Species
D. melanogaster
Name
FlyBase ID
FBal0146849
Feature type
allele
Associated gene
Dmel\rho
Associated Insertion(s)
P{GAL4}rhoiks
Carried in Construct
Also Known As
A0544
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Dubnau et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{GAL4}rhoiks
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Corl et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Intestinal stem cell proliferation levels are normal in rhoiks mutants.

      (Jiang et al., 2011)

      Mutant flies show increased sensitivity to ethanol-induced sedation compared to control flies.

      (Corl et al., 2009)

      Homozygous rhoiks mutants show increased sensitivity to ethanol vapor compared with controls. However rhoiks mutant flies do show reduced chronic tolerance to ethanol. Whereas control flies exhibit a reduced behavioural response following overnight pre-exposure to a low concentration of ethanol (never reaching intoxicating levels), a similar response in seen in rhoiks mutant flies with or without pre-exposure. No change in rapid tolerance is seen; as in controls, the flies exhibit a reduced behavioural response 3.5 hours following pre-exposure to intoxicating levels of ethanol.

      (Berger et al., 2008)

      In memory tests, mutants perform at 86% of wild-type after a single training session, at 48% after spaced training.

      (Dubnau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Etymology: Given the name "iks", after one of Pavlov's dogs.

      (Dubnau et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      A0544
      (van Swinderen et al., 2009, Berger et al., 2008, Dubnau et al., 2003)
      iks
      (Berger et al., 2008)
      rho1A0544
      (Corl et al., 2009)
      rhoA0544
      (Jiang et al., 2011)
      rhoiks
      Name Synonyms
      Secondary FlyBase IDs
        References (5)