FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nec19
Open Close
General Information
Symbol
Dmel\nec19
Species
D. melanogaster
Name
FlyBase ID
FBal0146989
Feature type
allele
Associated gene
Dmel\nec
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Green et al., 2003)
ethyl methanesulfonate
(Green et al., 2003)
Progenitor genotype
Cytology
Description

FlyBase curator comment: The authors mistakenly used the 3 letter code Glu instead of Gln when describing this mutation. This is evident from the fact that the nec protein has a long glutamine stretch from 31--39.

(Green et al., 2003)

Amino acid replacement: Q32term.

(Green et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,157,988..7,157,988 [-]
Nucleotide change:

C7157988T

Amino acid change:

Q32term | nec-PA

Reported amino acid change:

Q32term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Green et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Within a few hours of eclosion, nec2/nec19 flies develop black cuticular patches. Necrotic patches are randomly distributed over most of the body surface, but occur preferentially at the proximal leg joints.

      (Green et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      "X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative.

      (Green et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nec19
      Name Synonyms
      Secondary FlyBase IDs
        References (1)