FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\milt186
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General Information
Symbol
Dmel\milt186
Species
D. melanogaster
Name
FlyBase ID
FBal0147012
Feature type
allele
Associated gene
Dmel\milt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Stowers et al., 2002)
Progenitor genotype
Cytology
Description

A 2bp deletion at amino acid 248 that introduces a frame shift in the coding region. This is predicted to preclude translation of two-thirds of the predicted protein.

(Stowers et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:7,052,140..7,052,141 [+]
Comment:

Reported as a 2 base pair deletion in codon 348, causing a frameshift.

(Stowers et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutant eyes show external morphological defects. The lamina has a regular array of cartridges and these cartridges are apparently normal in composition. Many cartridges are however smaller than wild-type. Mutant photoreceptor terminals lack mitochondria, and have a density of synaptic vesicle about half of controls. milt186/Df(2L)J-H and milt92/milt186 animals do not attain the third larval instar. These animals typically survive for 3-5 days. No animals are seen to progress before the second instar. Larvae are sluggish but exhibit robust withdrawal responses when poked.

      (Stowers et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated independently from milt92.

      (Stowers et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      milt186
      (Stowers et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)