FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MhcEMB-3b
Open Close
General Information
Symbol
Dmel\MhcEMB-3b
Species
D. melanogaster
Name
FlyBase ID
FBal0147780
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{MhcEMB-3b}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Swank et al., 2003)
Progenitor genotype
Mhc+memb
(Swank et al., 2003)
Carried in construct
P{MhcEMB-3b}
Cytology
Description

Exon 3a has been replaced by cDNA sequences encoding exon 3b.

(Swank et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The myofibrillar ultrastructure in the indirect flight muscle of animals carrying MhcEMB-3b in a Mhc10 background is identical to wild type at the pupal stage. However, 2 days after eclosion, the filament packing is disrupted, and the normal rigid hexagonal arrangement of thick and thin filaments is disturbed. The myofibrils appear cracked and frayed when viewed longitudinally, because of gaps between thick and thin filaments and/or loss of thick and thin filaments. The phenotype becomes progressively worse with age.

      (Swank et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MhcEMB-3b
      Name Synonyms
      Secondary FlyBase IDs
        References (1)