FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GαiUAS.cCa
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General Information
Symbol
Dmel\GαiUAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0147908
Feature type
allele
Associated gene
Dmel\Gαi
Associated Insertion(s)
Carried in Construct
P{UAS-Gαi}
Also Known As
UAS-Gαi
Key Links
Transgenic product class
cDNA
(Cai et al., 2003)
wild_type
(Cai et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Cai et al., 2003)
wild_type
(Cai et al., 2003)
Mutagen
in vitro construct
(Yu et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Gαi}
Cytology
Description

UASt sequences drive expression of Gαi cDNA.

(Cai et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gαi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      neuroblast, with Scer\GAL4sca-P309

      (Cai et al., 2003, Yu et al., 2003)

      spindle pole centrosome & astral microtubule, with Scer\GAL4sca-P309

      (Yu et al., 2003)
      Detailed Description
      Statement
      Reference

      100% of G-iα65AScer\UAS.cCa; Scer\GAL4sca-P309 embryos divide to produce equal sized daughters. In these equal size divisions, spindle geometry and placements are both symmetric.

      (Cai et al., 2003)

      Overexpression of G-iα65AScer\UAS.cCa, under the regulation of Scer\GAL4sca-P309 can lead to the uniform cortical localisation of all apical components, and the loss of Gβ13F, along with the production of prominent astral microtubules over both centrosomes. This symmetric astral microtubule association with both centrosomes is similar to the astral microtubules structure seen in dividing epithelial cells. Expression of G-iα65AScer\UAS.cCa, under the regulation of Scer\GAL4mat.αTub67C.T:Hsim\VP16, results in equal size division occurring in 83% of neuroblasts.

      (Yu et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A low level of symmetric neuroblast divisions occur in embryos maternally and zygotically homozygous for rapsP89, expressing G-iα65AScer\UAS.cCa driven by Scer\GAL4sca-P309. The number of asymmetric divisions is dramatically higher in otherwise genetically identical embryos, zygotically heterozygous for rapsP89.

      (Cai et al., 2003)

      Expression of G-iα65AScer\UAS.cCa, under the regulation of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a rapsunspecified background results in equal size division occurring in 62% of neuroblasts.

      (Yu et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      G-iα65AScer\UAS.cCa
      GαiScer\UAS.cCa
      GαiUAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)