FlyBase Allele Report: Dmel\inaE[KG08585]

General Information

Symbol

Dmel\inaE^KG08585

Species

D. melanogaster

Name

FlyBase ID

FBal0148237

Feature type

allele

Associated gene

Dmel\inaE

Associated Insertion(s)

P{SUPor-P}inaE^KG08585

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Lin et al., 2014)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}inaE^KG08585

Cytology

Description

Insertion 20bp downstream of the 5' junction of the 13th intron.

(Leung et al., 2008)

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:13,805,495..13,805,495

(Lin et al., 2014, Leung et al., 2008, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response

(Lin et al., 2014)

short lived | chemical conditional

(Lin et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

inaE^KG08585 mutants exhibit 50% decrease in mean lifespan and a 34% reduction in mean survival time under oxidative stress induced by paraquat compared with wild-typ.

(Lin et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

inaE^N125/inaE^KG08585 is an enhancer of abnormal neurophysiology | semidominant phenotype of trp^P365

(Leung et al., 2008)

inaE^KG08585/inaE^KG08585 is an enhancer of abnormal neurophysiology | semidominant phenotype of trp^P365

(Leung et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The electroretinogram phenotype of trp^P365 heterozygotes is enhanced by inaE^N125/inaE^KG08585 and by inaE^KG08585/inaE^KG08585.

(Leung et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

inaE^N125

(Leung et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG33174^KG08585

inaE^KG08585

(Tortoriello et al., 2021, Lin et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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