FB2026_02 , released June 18, 2026
Allele: Dmel\rolsT321
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General Information
Symbol
Dmel\rolsT321
Species
D. melanogaster
Name
FlyBase ID
FBal0150280
Feature type
allele
Associated gene
Dmel\rols
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Chen and Olson, 2001)
Mutagen
ethyl methanesulfonate
(Chen and Olson, 2001)
Progenitor genotype
Cytology
Description

Point mutation changes W to stop in an isoform 2 (ISO2; 5.4Kb) specific exon at residue 431.

(Chen and Olson, 2001)

Amino acid replacement: W?term.

(Chen and Olson, 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,012,478..12,012,478 [-]
Nucleotide change:

G12012478A

Reported nucleotide change:

G?A

Amino acid change:

W661term | rols-PB; W431term | rols-PC; W431term | rols-PE; W430term | rols-PF

Reported amino acid change:

W431term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

(Chen and Olson, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In rolsT321 homozygous embryos the developing body wall muscles exhibit a near complete block of myoblast fusion. An identical phenotype is seen in rolsT321/Df(3L)vin4 embryos.

      (Chen and Olson, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rolsT321
      Name Synonyms
      Secondary FlyBase IDs
        References (1)