FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\plets1
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General Information
Symbol
Dmel\plets1
Species
D. melanogaster
Name
FlyBase ID
FBal0150297
Feature type
allele
Associated gene
Dmel\ple
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pendleton et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: C415R.

(Pendleton et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:6,715,254..6,715,254 [-]
Nucleotide change:

T6715254C

Amino acid change:

C415R | ple-PA; C486R | ple-PB; C486R | ple-PC

Reported amino acid change:

C415R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Pendleton et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      plets1 males raised at 31°C have significant lower level of dopamine as compared with sibling males raised at 25°C.

      Homozygous plets1 males raised at the restrictive temperature (31[o]C) induce homosexual courtship behavior in plets1 mutant as well as wild type males.

      (Liu et al., 2009)

      plets1/Df(3L)XBB70 animals are viable at 18oC, show intermediate viability at 25oC and are not viable at 29oC. plets1/Df(3L)XBB70 animals have normal locomotor activity at the permissive temperature, but have reduced locomotor activity compared to wild type at 29oC. Homozygous flies have normal locomotor activity at 18oC, but have reduced locomotor activity compared to wild type at 25oC and 29oC. This reduced locomotor activity can be reversed by the addition of L-dopa to the food medium.

      (Pendleton et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      plets1
      (Liu et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)