FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mus312Z3997
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General Information
Symbol
Dmel\mus312Z3997
Species
D. melanogaster
Name
FlyBase ID
FBal0150330
Feature type
allele
Associated gene
Dmel\mus312
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Laurencon et al., 2004, Yildiz et al., 2002)
Progenitor genotype
Cytology
Description

FlyBase curator comment: This corrects the amino acid alteration as reported in FBrf0155944. The Q693 lesion is stated with respect to splice variant product C. In terms of mus312-PA this would be Q689, and in terms of mus312-PB it corresponds to Q674.

(Sekelsky, 2005.11.28)

Amino acid replacement: Q693term.

(Sekelsky, 2005.11.28)

Stated to be amino acid replacement: Q718@, however subsequent clarification, Sekelsky, 2005.11.28, personal communication to FlyBase, explains numbering problem and provides accurate statement.

(Yildiz et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,331,920..7,331,920 [+]
Nucleotide change:

C7331920T

Reported nucleotide change:

CAG?TAG

Amino acid change:

Q689term | mus312-PA; Q693term | mus312-PE

Reported amino acid change:

Q718term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Difference between reported substitution and curated substitution resolved through a personal communication with J. Sekelsky.

(Yildiz et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      X-ray irradiation of wild-type third-instar larvae induces cell cycle arrest within 1 hour. In contrast, X-ray irradiation of mus312Z3997/mus312D1 mutant larvae fails to induce cell cycle arrest.

      (Kondo and Perrimon, 2011)

      Mutant larvae are sensitive to nitrogen mustard and to methyl methanesulfonate (compared to control larvae).

      (Laurencon et al., 2004)

      mus312Z3997/mus312D1 animals have an X chromosome non-disjunction rate of 24%.

      (Yildiz et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Laurencon, Hawley and Burtis

      (Yildiz et al., 2002)
      Comments
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mus312Z3997
      (Kondo and Perrimon, 2011)
      mus312ZIII-3997
      (Laurencon et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)