FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eyaSD.SE.UAS
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General Information
Symbol
Dmel\eyaSD.SE.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0150507
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
P{UAS-eyaSD.SE}
Key Links
Transgenic product class
missense_variant
(Hsiao et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hsiao et al., 2001)
Mutagen
in vitro construct
(Hsiao et al., 2001)
Progenitor genotype
eyaUAS.cHa
(Hsiao et al., 2001)
Carried in construct
P{UAS-eyaSD.SE}
Cytology
Description

Construct: Amino acid replacement: S?D. Amino acid replacement: S?E.

(Hsiao et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
eya
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average penetrance of ectopic eye induction in eyaSD.SE.Scer\UAS; Scer\GAL4dpp.blk1 flies is 81% (over 8 independent P{UAS-eyaSD.SE} insertions). Ectopic eye patches seen in these flies are larger and more numerous than those seen in eyaScer\UAS.cHa; Scer\GAL4dpp.blk1flies. i.e. - the penetrance and expressivity of ectopic eye phenotypes is higher than that seen in eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies. The penetrance of ectopic eye induction in eyaSD.SE.Scer\UAS; Scer\GAL4dpp.blk1 flies is reduced from 92% (n=325) to 76% (n=322) by heterozygosity for eyaG130 (data from a single, 'strong' P{UAS-eyaSD.SE} insertion). eyaSD.SE.Scer\UAS; Scer\GAL4dpp.PH flies have highly variable wing defects, including ectopic bristles on L3 and in more extreme cases, blistering, and defects in overall shape: Proportion with blistered wings = 41%; proportion with only mild wing defects = 59%. These flies also have increased numbers of scutellar machrochaete (average= 5.6, compared to 4 in wild-type and 6.0 in eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies). Note: all of the above data are averages from 8 independent P{UAS-eyaSD.SE} insertions.

      (Hsiao et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of ectopic eye induction in eyaSD.SE.Scer\UAS; Scer\GAL4dpp.blk1 flies is reduced from 92% (n=325) to 80% (n=303) by heterozygosity for eyaG130 (data from a single, 'strong' P{UAS-eyaSD.SE} insertion).

      (Hsiao et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      These mutations are designed to mimic phosphorylation of 2 putatuve MAPK sites in eya.

      (Hsiao et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eyaSD.SE.Scer\UAS
      eyaSD.SE.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)