FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eyaD493N.UAS
Open Close
General Information
Symbol
Dmel\eyaD493N.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0151945
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
P{UAS-eya.D493N.b}
Also Known As
eyaD493N
Key Links
Transgenic product class
missense_variant
(Rayapureddi et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rayapureddi et al., 2003)
Mutagen
in vitro construct
(Rayapureddi et al., 2003, Tootle et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-eya.D493N.b}
Cytology
Description

Expression of mutated eya (carries the amino acid replacement D493N) is driven by UASt sequences.

(Rayapureddi et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
eya
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The level of ectopic eye induction with eyaD493N.Scer\UAS; Scer\GAL4dpp.blk1 is less than 5%, compared with around 50% for eyaScer\UAS.cHa; Scer\GAL4dpp.blk1.

      (Tootle et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      eyaD493N.UAS/Scer\GAL4ey.PB partially rescues eya2

      (Rayapureddi et al., 2003)

      eyaD493N.UAS/Scer\GAL4dpp.blk1 partially rescues eya2

      (Tootle et al., 2003)
      Comments

      eyaD493N.Scer\UAS; Scer\GAL4ey.PB partially rescues the loss of eye phenotype of eya2 mutant flies. The eyes of these flies are significantly smaller than those of eya2 flies rescued with eyScer\UAS.cHa and Scer\GAL4ey.PB.

      (Rayapureddi et al., 2003)

      eyaD493N.Scer\UAS; Scer\GAL4dpp.blk1 rescue of eyes in eya2 flies has a penetrance of under 60% (compared to 100% penetrance due to rescue by eyaScer\UAS.cHa), whereas the size of rescued eyes is 5-25% of wild-type size (compared with around 50-80% due to rescue by eyaScer\UAS.cHa).

      (Tootle et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      In vitro assays show that this mutated form of eya lacks phosphatase activity.

      (Rayapureddi et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eyaD493N.Scer\UAS
      eyaD493N.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)