FlyBase Allele Report: Dmel\Cyfip[unspecified]

General Information

Symbol

Dmel\Cyfip^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0152178

Feature type

allele

Associated gene

Dmel\Cyfip

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

No midline crossing of longitudinal connectives is seen in heterozygotes.

(Schenck et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Cyfip^unspecified is an enhancer of larval intersegmental nerve phenotype of Rac1^V12.UAS, Scer\GAL4^elav-C155

(Schenck et al., 2003)

Cyfip^unspecified is an enhancer of eye | posterior phenotype of Rac1^V12.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Cyfip^unspecified is an enhancer of ommatidium phenotype of Rac1^V12.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Cyfip^unspecified is an enhancer of ommatidium phenotype of Fmr1^EP3517, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Cyfip^unspecified is an enhancer of synapse phenotype of Fmr1^EP3517, Scer\GAL4^elav-C155

(Schenck et al., 2003)

Cyfip^unspecified, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Fmr1^EP3517, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

NOT Enhancer of

Statement

Reference

Cyfip^unspecified is a non-enhancer of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Cyfip^unspecified is a non-enhancer of ommatidium phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

NOT Suppressor of

Statement

Reference

Cyfip^unspecified is a non-suppressor of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Cyfip^unspecified is a non-suppressor of ommatidium phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Schenck et al., 2003)

Other

Statement

Reference

Cyfip^unspecified, Fmr1^EP3517, Scer\GAL4^GMR.PF has eye phenotype

(Schenck et al., 2003)

Cyfip^unspecified, Fmr1^EP3517, Scer\GAL4^GMR.PF has ommatidium phenotype

(Schenck et al., 2003)

Cyfip^unspecified, Rac1^V12.UAS, Scer\GAL4^elav-C155 has larval longitudinal connective phenotype

(Schenck et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The combination of Sra-1^unspecified and Rac1^V12.Scer\UAS driven by Scer\GAL4^GMR.PF has a stronger eye phenotype than Rac1^V12.Scer\UAS (driven by Scer\GAL4^GMR.PF) alone. The combination of heterozygous Sra-1^unspecified and Fmr1^EP3517 (driven by Scer\GAL4^GMR.PF) gives a strong eye phenotype, stronger than Scer\GAL4^GMR.PF driven by Scer\GAL4^GMR.PF. Eyes are of reduced size and contain areas lacking in ommatidia. The combination of heterozygous Sra-1^unspecified and Fmr1^EP3517 (driven by Scer\GAL4^elav-C155) gives a strong eye phenotype, stronger than Scer\GAL4^GMR.PF driven by Scer\GAL4^GMR.PF. Eyes are of reduced size and contain areas lacking in ommatidia. These phenotypes are enhanced by heterozygous Sra-1^unspecified (Stalling reaches 53%). In Rac1^V12.Scer\UAS, Scer\GAL4^elav-C155 embryos combined with heterozygous Sra-1^unspecified, midline crossing of longitudinal connectives is seen.

(Schenck et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cyfip^unspecified

Sra-1^unspecified

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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