FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sin3Ae374
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General Information
Symbol
Dmel\Sin3Ae374
Species
D. melanogaster
Name
FlyBase ID
FBal0152186
Feature type
allele
Associated gene
Dmel\Sin3A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    8bp deletion approximately 50bp downstream of the Sin3A translation initiation codon.

    (Pile et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes raised on medium containing trichostatin A (TSA) do not show an increase in the rate of lethality or developmental delay compared to wild-type flies raised on medium containing TSA.

        (Pile et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Sin3Ae374 is partially rescued by Sin3A220.UAS.Tag:HA/Scer\GAL4αTub84B.PL

        (Spain et al., 2010)

        Sin3Ae374 is partially rescued by Sin3A220.UAS.Tag:HA/Sin3A187.UAS.Tag:HA/Scer\GAL4αTub84B.PL

        (Spain et al., 2010)
        Not rescued by

        Sin3Ae374 is not rescued by Sin3A187.UAS.Tag:HA/Scer\GAL4αTub84B.PL

        (Spain et al., 2010)
        Comments

        The lethality of Sin3Ae374 homozygotes is not rescued by expression of Sin3A187.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL.

        The lethality of Sin3Ae374 homozygotes is partially rescued by expression of Sin3A220.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL (66% viability).

        The lethality of Sin3Ae374 homozygotes is partially rescued by co-expression of both Sin3A187.Scer\UAS.T:Ivir\HA1 and Sin3A220.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL (81% viability).

        (Spain et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Sin3Ae374
        (Spain et al., 2010)
        dSin3Ae374
        (Biryukova and Heitzler, 2008)
        sin3e374
        (Pile et al., 2001)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)