FB2026_02 , released June 18, 2026
Allele: Dmel\Sema5c23-2
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General Information
Symbol
Dmel\Sema5c23-2
Species
D. melanogaster
Name
FlyBase ID
FBal0152189
Feature type
allele
Associated gene
Dmel\Sema5c
Associated Insertion(s)
P{lacW}Sema5c23-2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Woodhouse et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacW}Sema5c23-2
Cytology
Description

The insertion is 46bp from the start of the translated region of the Sema-5c gene.

(Woodhouse et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Sema5c23-2 is a suppressor of neoplasia phenotype of l(2)gl4

      (Woodhouse et al., 2003)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Sema5c23-2 is a non-suppressor of larval brain phenotype of l(2)gl4

      (Woodhouse et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When mutant larval brain tissue is transplanted from animals homozygous for l(2)gl4 and also homozygous for Sema-5c23-2, a suppression of the normal tumorigenesis and metastasis phenotypes is seen. The addition of Sema-5c23-2 to l(2)gl4 larvae has no gross effect on the larval brain pehnotype.

      (Woodhouse et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sema-5c23-2
      Sema5c23-2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)