FB2026_03 , released September 17, 2026
Allele: Dmel\RhoGEF64C1
Open Close
General Information
Symbol
Dmel\RhoGEF64C1
Species
D. melanogaster
Name
FlyBase ID
FBal0152493
Feature type
allele
Associated gene
Dmel\RhoGEF64C
Associated Insertion(s)
P{EP}EP3035
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bashaw et al., 2001)
P-element activity
(Bashaw et al., 2001)
Progenitor genotype
RhoGEF64CEP3035
(Bashaw et al., 2001)
Associated Insertion(s)
P{EP}EP3035
Cytology
Description

The P{EP}RhoGEF64CEP3035 insertion present in the progenitor line is also still present.

(Bashaw et al., 2001)

Amino acid replacement: Q581term.

(Bashaw et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,766,633..4,766,633 [+]
Nucleotide change:

C4766633T

Amino acid change:

Q582term | RhoGEF64C-PA; Q582term | RhoGEF64C-PB

Reported amino acid change:

Q581term

Comment:

The point mutation was introduced onto a chromosome containing the P{EP}EP3035 insertion.

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Bashaw et al., 2001)
transposable_element_insertion_site
3L:4,692,823..4,692,823 [+]
(Bashaw et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gef64C1 under the control of Scer\GAL4elav.PLu (using the P{EP}Gef64CEP3035 insertion present on the Gef64C1 chromosome) does not result in a gain of function defective axon guidance phenotype.

      (Bashaw et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos that are both maternally and zygotically mutant for RhoGEF204291 and are also heterozygous or homozygous for Gef64C1 show a mild increase in the frequency of spiracle defects compared to embryos that are both maternally and zygotically mutant for RhoGEF204291 in a Gef64C+ background.

      (Simões et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gef64C1
      RhoGEF64C1
      Rhogef64C1
      (Simões et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)