FB2026_03 , released September 17, 2026
Allele: Dmel\Act57B+t7BBH
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General Information
Symbol
Dmel\Act57B+t7BBH
Species
D. melanogaster
Name
FlyBase ID
FBal0152804
Feature type
allele
Associated gene
Dmel\Act57B
Associated Insertion(s)
Carried in Construct
P{Act57B.t7BBH}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Davis et al., 2003)
wild_type
(Davis et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Davis et al., 2003)
wild_type
(Davis et al., 2003)
Mutagen
in vitro construct
(Davis et al., 2003)
Progenitor genotype
Carried in construct
P{Act57B.t7BBH}
Cytology
Description

A 15.5kb BamHI/HpaI genomic fragment including the entire Act57B ORF plus about 5kb of 3' sequence and 5' sequence extending all the way to the BamHI site in Rx exon 6.

(Davis et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
Act57B
Encoded product / tool
Act57B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2R:20,935,808..20,951,398 [+]
Linked to:
BamHI-HpaI restriction fragment
Comment:

Act57B+t7BBH prevents prepupal lethality in Act57Bex8/Df(2R)E2 animals and also partially rescues ellipsoid body morphology in the larval brains of Act57Bex8 homozygotes; position of restriction fragment on reference sequence inferred by FlyBase curator.

(Davis et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Act57B+t7BBH partially rescues Act57Bex8

      (Davis et al., 2003)

      Act57B+t7BBH partially rescues Df(2R)E2/Act57Bex8

      (Davis et al., 2003)
      Comments

      Act57B+t7BBH prevents prepupal lethality in Act57Bex8/Df(2R)E2 animals. The majority of these animals die as pharate adults, and all escaper adults lack a clypeus. Act57B+t7BBH also partially rescues ellipsoid body morphology in the larval brains of Act57Bex8 homozygotes.

      (Davis et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Act57B+t.7BBH
      Act57B+t7BBH
      Name Synonyms
      Secondary FlyBase IDs
        References (1)