FlyBase Allele Report: Dmel\nvy[V523P.UAS.Tag:MYC]

General Information

Symbol

Dmel\nvy^{V523P.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0154820

Feature type

allele

Associated gene

Dmel\nvy

Associated Insertion(s)

Carried in Construct

P{UAS-nvy.V523P}

Key Links

Transgenic product class

missense_variant

(Terman and Kolodkin, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Terman and Kolodkin, 2004)

Mutagen

in vitro construct

(Terman and Kolodkin, 2004)

Progenitor genotype

Carried in construct

P{UAS-nvy.V523P}

Cytology

Description

UAS regulatory sequences drive expression of a mutated form of nvy (carries the amino acid replacement V523P). The protein is tagged with the Tag:MYC epitope.

(Terman and Kolodkin, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

nvy

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

Phenotype Manifest In

larval abdominal intersegmental nerve, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

larval abdominal segmental nerve, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

larval ventral nerve cord, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

lateral longitudinal fascicle, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

presumptive embryonic/larval central nervous system, with Scer\GAL4^elav-C155

(Terman and Kolodkin, 2004)

Detailed Description

Statement

Reference

When expression is driven by Scer\GAL4^elav-C155 increased axonal repulsion is evident in central and peripheral nervous systems. The majority of defects are manifest as an increase in repulsion.

(Terman and Kolodkin, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

nvy^{V523P.Scer\UAS.T:Hsap\MYC}

nvy^{V523P.Scer\UAS.T:Myc}

nvy^{V523P.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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