FB2025_05 , released December 11, 2025
Gene: Dmel\nvy
Open Close
General Information
Symbol
Dmel\nvy
Species
D. melanogaster
Name
nervy
Annotation Symbol
CG3385
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005636
Gene Model Status
Current
Stock Availability
39 publicly available
Gene Summary
nervy (nvy) is a member of the MTG family of genes that have both nuclear and cytosolic functions. nvy encodes a transcriptional repressor and an A kinase anchoring protein (AKAP). It regulates repulsive axon guidance and functions in Plexin and Notch signaling pathways. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
60C5-60C6
Sequence location
Recombination map
2-106
RefSeq locus
NT_033778 REGION:24275734..24291084
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables transcription corepressor activity
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR013289
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Terman and Kolodkin, 2004)
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Wildonger and Mann, 2005)
involved_in circadian rhythm
inferred from mutant phenotype
(Duvall and Taghert, 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in DNA-templated transcription
inferred from electronic annotation with InterPro:IPR003894, InterPro:IPR037249
(InterPro Project Members, 2004-)
involved_in negative regulation of DNA-templated transcription
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR013289
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Wildonger and Mann, 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
nervy (nvy) is a member of the MTG family of genes that have both nuclear and cytosolic functions. nvy encodes a transcriptional repressor and an A kinase anchoring protein (AKAP). It regulates repulsive axon guidance and functions in Plexin and Notch signaling pathways. [Date last reviewed: 2018-09-20]
Summary (Interactive Fly)

probable transcriptional co-repressor - described as an AKAP binding protein, zinc finger protein expressed in the CNS and involved in axon guidance - required for proper morphogenesis of sensory neuron dendrites

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\nvy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KEZ2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216885.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
nvy-RA
FBtr0072267
NM_079117
3426
743
nvy-RB
FBtr0330610
NM_001274235
3097
742
nvy-RC
FBtr0330611
NM_001274236
3104
742
nvy-RD
FBtr0330612
NM_001274237
3426
757
Additional Transcript Data and Comments
Reported size (kB)

3.243 (longest cDNA)

(Feinstein et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
nvy-PA
FBpp0072174
76.5
743
8.37
Q9W186
NP_523841
AAF47191
nvy-PB
FBpp0303460
76.4
742
8.37
A0A0B4KFZ8
NP_001261164
AGB93694
nvy-PC
FBpp0303461
76.4
742
8.37
A0A0B4KFZ8
NP_001261165
AGB93695
nvy-PD
FBpp0303462
78.2
757
9.01
A0A0B4KEZ2
NP_001261166
AGB93696
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

742 aa isoforms: nvy-PB, nvy-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

743 (aa); 76 (kD)

(Feinstein et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nvy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.84

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
organism | subset
(Fisher et al., 2012)
embryonic stage 7 -- 8
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 9 -- 17
neuroblast
(Feinstein et al., 1995)
presumptive embryonic/larval peripheral nervous system | restricted
(Feinstein et al., 1995)
central nervous system | restricted
(Feinstein et al., 1995)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
larval midline neuron
(Kearney et al., 2004)
Additional Descriptive Data

nvy is expressed in a complex and dynamic pattern. It is restricted to precursors of the central and peripheral nervous system. At certain stages, nvy is expressed in more cells or at higher levels in thoracic segments than in abdominal segments. These stages are separated by stages in which the expression pattern is the same in all segments. In later embryos, most of the nvy-expressing cells are in the posterior compartments of segments. nvy was shown to be induced by ubiquitous Ubx expression. nvy expression in various homeotic mutant backgrounds was also described.

(Feinstein et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
larval central nervous system | subset
(Ice et al., 2005)
larval peripheral nervous system | subset
(Ice et al., 2005)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Wildonger and Mann, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nvy in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of nvy
Transgenic constructs containing regulatory region of nvy
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4neur-GAL4-A101
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy, with Scer\GAL4elav-C155
Phenotype manifest in
Allele
adult thorax & mechanosensory sensory organ, with Scer\GAL4sca-537.4
adult thorax & mechanosensory sensory organ | somatic clone, with Scer\GAL4αTub84B.PZ
adult thorax | dorsal & mechanosensory sensory organ, with Scer\GAL4pnr-MD237
cuticle | somatic clone, with Scer\GAL4pnr-MD237
larval abdominal intersegmental nerve, with Scer\GAL4elav-C155
larval abdominal segmental nerve, with Scer\GAL4elav-C155
larval ventral nerve cord, with Scer\GAL4elav-C155
lateral longitudinal fascicle, with Scer\GAL4elav-C155
mechanosensory neuron | somatic clone, with Scer\GAL4neur-GAL4-A101
mechanosensory neuron | somatic clone, with Scer\GAL4pnr-MD237
mechanosensory sensory organ, with Scer\GAL4sca-C253
mechanosensory sensory organ & thorax, with Scer\GAL4pnr-MD237
mechanosensory sensory organ | somatic clone, with Scer\GAL4neur-GAL4-A101
mechanosensory sensory organ | somatic clone, with Scer\GAL4pnr-MD237
medial longitudinal fascicle, with Scer\GAL4elav-C155
presumptive embryonic/larval central nervous system, with Scer\GAL4elav-C155
sensory mother cell | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PZ
sensory mother cell | somatic clone, with Scer\GAL4αTub84B.PZ
thecogen cell | somatic clone, with Scer\GAL4neur-GAL4-A101
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\CBFA2T3
13 of 14
Yes
Yes
1  
Hsap\CBFA2T2
12 of 14
No
Yes
1  
Hsap\RUNX1T1
12 of 14
No
Yes
3  
Hsap\TDRD1
1 of 14
No
No
Hsap\ZMYND8
1 of 14
No
No
1  
Hsap\ZMYND11
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Cbfa2t3
13 of 14
Yes
Yes
Rnor\Cbfa2t2
12 of 14
No
Yes
Rnor\Runx1t1
12 of 14
No
Yes
Rnor\Zmynd8
1 of 14
No
No
Rnor\Zmynd11
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Cbfa2t3
13 of 14
Yes
Yes
Mmus\Cbfa2t2
12 of 14
No
Yes
Mmus\Runx1t1
12 of 14
No
Yes
Mmus\Zmynd8
1 of 14
No
No
Mmus\Zmynd11
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\cbfa2t3
8 of 13
Yes
Yes
Xtro\cbfa2t2
7 of 13
No
Yes
Xtro\fbrs
1 of 13
No
Yes
Xtro\runx1t1
1 of 13
No
Yes
Xtro\zmynd11
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\cbfa2t3
12 of 14
Yes
Yes
Drer\cbfa2t2
11 of 14
No
Yes
Drer\runx1t1
11 of 14
No
Yes
Drer\prkcbp1l
1 of 14
No
No
Drer\zmynd8
1 of 14
No
No
Drer\zmynd11
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\bra-1
1 of 14
Yes
No
Cele\bra-2
1 of 14
Yes
No
Cele\F07A11.4
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP010867
8 of 12
Yes
Yes
Agam\AgaP_AGAP002840
1 of 12
No
No
Agam\AgaP_AGAP002983
1 of 12
No
No
Agam\AgaP_AGAP004905
1 of 12
No
No
Agam\AgaP_AGAP011638
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\UBP16
1 of 13
Yes
No
Atha\UBP17
1 of 13
Yes
No
Atha\UBP18
1 of 13
Yes
No
Atha\UBP19
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:nvy. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Zmynd8
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CBFA2T3; CBFA2/RUNX1 partner transcriptional co-repressor 3
13 of 14
603870
       
      CBFA2T2; CBFA2/RUNX1 partner transcriptional co-repressor 2
      12 of 14
      603672
           
          RUNX1T1; RUNX1 partner transcriptional co-repressor 1
          12 of 14
          RUNT-RELATED TRANSCRIPTION FACTOR 1, TRANSLOCATED TO, 1; RUNX1T1
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              nvy
              suppressible
              ase
              (Wildonger and Mann, 2005)
              nvy
              suppressible
              da
              (Wildonger and Mann, 2005)
              nvy
              suppressible
              sens
              (Wildonger and Mann, 2005)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              ase
              suppressible
              nvy
              (Wildonger and Mann, 2005)
              da
              enhanceable
              nvy
              (Wildonger and Mann, 2005)
              da
              suppressible
              nvy
              (Wildonger and Mann, 2005)
              sc
              suppressible
              nvy
              (Wildonger and Mann, 2005)
              External Data
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-106
              Cytogenetic map
              60C5-60C6
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              60C5-60C6
              Limits computationally determined from genome sequence between P{lacW}Nop60Bk05318 and P{PZ}bs03267&P{lacW}l(2)k10502k10502
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              60C-60C
              (Feinstein et al., 1999)
              99F-99F
              (Mann, 1995.2.24)
              60C-60C
              (determined by in situ hybridisation)
              (Mann, 1999.8.31)
              Map location of 99F reported in FBrf0081987 was an error.
              (Mann, 1999.8.31)
              Experimentally Determined Recombination Data
              Location

              2-106

              (FlyBase, 2016)

              2-110.5

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (39)
              Genomic Clones (23)
              cDNA Clones (95)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  dsRNA has been made from templates generated with primers directed against this gene. RNAi of nvy results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

                  (Parrish et al., 2006)

                  nvy couples cAMP-PKA signaling to plexA to regulate Sema-1a-mediated axon repulsion. nvy and Sema-1a function in the same signaling pathway but have opposing effects. nvy acts downstream of Sema-1a to regulate repulsive axon guidance.

                  (Terman and Kolodkin, 2004)

                  "60C" was stated as revision.

                  (Feinstein et al., 1999)

                  The expression of nvy in a subset of delaminating neuroblasts during the early stages of neurogenesis suggest a role for nvy in neuroblast determination.

                  (Abu-Shaar et al., 1995)

                  Isolated during a subtractive hybridisation protocol to identify Ubx-activated target genes. Ubx inducible during embryogenesis.

                  (Feinstein et al., 1995)
                  Relationship to Other Genes
                  Source for database merge of
                  Additional comments
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: nvy CG3385

                  (Wang, 1999.11)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (5)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  References (91)