FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(3)mbtGM161
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General Information
Symbol
Dmel\l(3)mbtGM161
Species
D. melanogaster
Name
FlyBase ID
FBal0155051
Feature type
allele
Associated gene
Dmel\l(3)mbt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yohn et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: H1161Y.

(Yohn et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,267,456..27,267,456 [-]
Nucleotide change:

C27267456T

Amino acid change:

H1161Y | l(3)mbt-PB

Reported amino acid change:

H1161Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Yohn et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos resulting from l(3)mbtGM161 germ-line clones have reduced numbers of germ cells compared to wild-type embryos.

      (Yohn et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      In trans Df(3R)D605 or Df(3R)mbtPE3, l(3)mbt alleles form the following phenotypic series: l(3)mbtGM161 < l(3)mbtts1 < l(3)mbtGM79 < l(3)mbtE2 < l(3)mbtGM76. Phenotypes range from weak maternal-effect mitotic asynchrony to a severe mitotic block to oogenesis defects in trans-heterozygous females. Each of these phenotypes is temperature sensitive: phenotypes increase in severity as the temperature is raised from 18 to 29oC.

      (Yohn et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      l(3)mbtGM161
      Name Synonyms
      Secondary FlyBase IDs
        References (1)