FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ClicEY04209
Open Close
General Information
Symbol
Dmel\ClicEY04209
Species
D. melanogaster
Name
FlyBase ID
FBal0155136
Feature type
allele
Associated gene
Dmel\Clic
Associated Insertion(s)
P{EPgy2}ClicEY04209
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}ClicEY04209
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  central nervous system cancer
      modeled by dpnUAS.cUa
      (Francisco et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous female and hemizygous male ClicEY04209 flies are lethal at 25[o]C. Heterozygous ClicEY04209 females are fertile and appear morphologically normal and generally healthy.

      In an eRING assay to assess ethanol behavior, ClicEY04209 heterozygous females maintain their negative geotaxis behavior for longer than controls, during exposure to ethanol, suggesting that these mutants have reduced sensitivity to the sedative effects of ethanol. ClicEY04209 hemizygous males and homozygous females (reared at 20[o]C to improve viability) exhibit diminished ethanol sensitivity. In contrast to the effect on ethanol sensitivity, no significant effect on rapid ethanol tolerance is found.

      Climbing speed in negative geotaxis assays is indistinguishable in ClicEY04209 heterozygotes compared to controls.

      (Bhandari et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ClicEY04209
      (Francisco et al., 2020, Bhandari et al., 2012, Popodi et al., 2010-)
      l(1)G0053EY04209
      Name Synonyms
      Secondary FlyBase IDs
        References (4)