FlyBase Gene Report: Dmel\Clic

General Information

Symbol

Dmel\Clic

Species

D. melanogaster

Name

Chloride intracellular channel

Annotation Symbol

CG10997

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030529

Gene Model Status

Current

Stock Availability

23 publicly available

Enzyme Name (EC)

glutathione peroxidase (1.11.1.9)

Gene Summary

Chloride intracellular channel (Clic) encodes a protein involved in chloride transport and alcohol-related behavior. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DmCLIC, l(1)G0053, l(1)G0472

Key Links

Genomic Location

Cytogenetic map

12C5-12C6

Sequence location

X:13,812,971..13,822,307 [-]

Recombination map

1-46

RefSeq locus

NC_004354 REGION:13812971..13822307

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from direct assay

(Littler et al., 2008)

enables chloride channel activity

inferred from direct assay

(Littler et al., 2008)

enables lipid binding

inferred from direct assay

(Littler et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables chloride channel activity

inferred from biological aspect of ancestor with PANTHER:PTN002258658

(GO Reference Genome Project, 2011-)

enables glutathione peroxidase activity

inferred from sequence or structural similarity with UniProtKB:O15247

(Gene Ontology Curators, 2002-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in chloride transport

inferred from direct assay

(Littler et al., 2008)

involved_in negative gravitaxis

inferred from direct assay

(Bhandari et al., 2012)

involved_in response to alcohol

inferred from direct assay

(Bhandari et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in chloride transport

inferred from biological aspect of ancestor with PANTHER:PTN002258658

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in mitochondrial membrane

inferred from direct assay

(Ponnalagu et al., 2016)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in apical plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002889618

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002258658

(GO Reference Genome Project, 2011-)

located_in membrane

inferred by curator from GO:0005254

(Littler et al., 2008)

Gene Group (FlyBase)

INTRACELLULAR CHLORIDE CHANNEL FAMILY

GLUTATHIONE PEROXIDASES

Protein Family (UniProt)

Belongs to the chloride channel CLIC family. (Q9VY78)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

glutathione peroxidase activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O (1.11.1.9)

RHEA 16833:

Summaries

Gene Snapshot

Chloride intracellular channel (Clic) encodes a protein involved in chloride transport and alcohol-related behavior. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

INTRACELLULAR CHLORIDE CHANNEL FAMILY -: The intracellular chloride channel (CLIC) family can exist as both monomeric soluble proteins and integral membrane proteins in organelles where they function as chloride-selective ion channels. CLIC proteins are characterised by the presence of a 240 residue CLIC module, whose structure belongs to the GST-fold superfamily. (Adapted from FBrf0204349 and FBrf0232068).
GLUTATHIONE PEROXIDASES -: Glutathione peroxidases are oxidoreductases that effectively reduces hydrogen peroxide and lipid peroxides to water and lipid alcohols, respectively, and in turn oxidizes glutathione to glutathione disulfide. (Adapted from PMID:20981034).

Protein Function (UniProtKB)

Might insert into membranes and form chloride ion channels (PubMed:17985355). Channel activity depends on the pH (PubMed:17985355). May play a role in ethanol sensitivity (PubMed:22239914).

(UniProt, Q9VY78)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Clic for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VY78)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

2YV7

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Clic-RA

FBtr0073835

NM_132700

1839

260

Clic-RC

FBtr0346089

NM_001272608

1349

260

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Clic-PA

FBpp0073666

30.2

260

6.24

FBpp0311923

30.2

260

6.24

Q9VY78

NP_001259537

AGB95379

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

260 aa isoforms: Clic-PA, Clic-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

(UniProt, Q9VY78)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

2YV7

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VY78

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Clic using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in mitochondrial membrane

inferred from direct assay

(Ponnalagu et al., 2016)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: P{PTT-GC}Clic^G00264

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

nurse cell

• cytoplasm

(Cooley et al., 2003.5)

Reporter: PBac{754.P.FSVS-0}Clic^CPTI003213

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: low expression throughout adult brain

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Clic in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Clic

View exonic expression by tissue for Dmel\Clic

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030529

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32349/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030529

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030529

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10997

Flygut - An atlas of the Drosophila adult midgut

FBgn0030529

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Clic

Transgenic constructs containing regulatory region of Clic

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene duplicated in

Dp(1;3)DC275

(Popodi et al., 2010-, Venken et al., 2010)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Clic^KK101604

lethal, with Scer\GAL4^Mef2.PR

Clic^GD12617

lethal | heat sensitive

partially lethal - majority die | female

partially lethal - majority die | male

partially lethal - majority die | recessive

Clic^G0472

viable

Clic^EY01352

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Clic^GD12617

viable, with Scer\GAL4^pnr-MD237

Clic^GD12617

viable, with Scer\GAL4^tin.CΔ4

Clic^GD12617

Sterility

Allele

fertile

Clic^EY01352

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

visible, with Scer\GAL4^pnr-MD237

Clic^GD12617

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

Clic^GD12617

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\CLIC2

10 of 14

Yes

Hsap\CLIC1

9 of 14

Yes

Hsap\CLIC3

9 of 14

Yes

Hsap\CLIC4

9 of 14

Yes

Hsap\CLIC5

8 of 14

Yes

Hsap\CLIC6

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Clic2

10 of 14

Yes

Rnor\Clic5

10 of 14

Yes

Rnor\Clic1

9 of 14

Yes

Rnor\Clic3

9 of 14

Yes

Rnor\Clic4

9 of 14

Yes

Rnor\Clic6

5 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Clic5

10 of 14

Yes

Mmus\Clic1

9 of 14

Yes

Mmus\Clic3

8 of 14

Yes

Mmus\Clic4

8 of 14

Yes

Mmus\Clic6

5 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\clic4

8 of 13

Yes

Xtro\clic5

8 of 13

Yes

Xtro\clic1

5 of 13

Yes

Xtro\clic6

5 of 13

Yes

Xtro\clic3

4 of 13

Yes

Xtro\ntng2

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\clic5a

11 of 14

Yes

Drer\clic2

10 of 14

Yes

Drer\clic1

9 of 14

Yes

Drer\clic4

9 of 14

Yes

Drer\LOC100333907

9 of 14

Yes

Drer\clic5b

7 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\exc-4

12 of 14

Yes

Cele\exl-1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP000943

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (28)

Atha\DHAR1

6 of 13

Yes

Atha\DHAR2

6 of 13

Yes

Atha\DHAR3

6 of 13

Yes

Atha\AT1G19550

5 of 13

Yes

Atha\AT5G36270

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\CAM1

1 of 13

Yes

Scer\GTT2

1 of 13

Yes

Scer\TEF4

1 of 13

Yes

Scer\YGR201C

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (1)

Ecol\sspA

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Clic. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CLIC5; chloride intracellular channel 5

model of autosomal recessive nonsyndromic deafness 103

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Clic^EY04209

ameliorates central nervous system cancer

modeled by dpn^UAS.cUa

(Francisco et al., 2020)

Clic^G0472

ameliorates central nervous system cancer

modeled by dpn^UAS.cUa

(Francisco et al., 2020)

Clic^KK101604

ameliorates central nervous system cancer

modeled by dpn^UAS.cUa

(Francisco et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CLIC2; chloride intracellular channel 2

10 of 14

300138

CLIC1; chloride intracellular channel 1

9 of 14

602872

CLIC3; chloride intracellular channel 3

9 of 14

606533

CLIC4; chloride intracellular channel 4

9 of 14

606536

CLIC5; chloride intracellular channel 5

8 of 14

607293

DEAFNESS, AUTOSOMAL RECESSIVE 103; DFNB103

autosomal recessive nonsyndromic deafness 103

CLIC6; chloride intracellular channel 6

5 of 14

615321

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Clic - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Ar2

experimental knowledge based

(Guruharsha et al., 2011)

Clic - CG10265

experimental knowledge based

(Guruharsha et al., 2011)

Clic - CG1910

experimental knowledge based

(Guruharsha et al., 2011)

Clic - CG2852

experimental knowledge based

(Guruharsha et al., 2011)

Clic - CG5568

experimental knowledge based

(Guruharsha et al., 2011)

Clic - CG7737

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Gs1

experimental knowledge based

(Guruharsha et al., 2011)

Clic - GstO3

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Gtpx

experimental knowledge based

(Guruharsha et al., 2011)

Clic - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Hibch

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Mdh2

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Pgd

experimental knowledge based

(Guruharsha et al., 2011)

Clic - RabX1

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Sps1

experimental knowledge based

(Guruharsha et al., 2011)

Clic - Synd

experimental knowledge based

(Guruharsha et al., 2011)

Clic - eEF5

experimental knowledge based

(Guruharsha et al., 2011)

Clic - r-l

experimental knowledge based

(Guruharsha et al., 2011)

Clic - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030529

MIST (protein-protein) - An integrated Molecular Interaction Database

32349

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-46

Cytogenetic map

12C5-12C6

Sequence location

X:13,812,971..13,822,307 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

12C5-12C6

Limits computationally determined from genome sequence between P{EP}CG33174^EP1101 and P{EP}EP1595^EP1595

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

12C-12D

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.12.2)

Experimentally Determined Recombination Data

Location

1-46

(FlyBase, 2016)

1-44.2

(Comeron et al., 2012)

(Berryman and Tanda, 2005)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (23)

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (99)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD46306

Other clones

DPiM_LD46306

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030529

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030529

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

S2R+-NPT005

Other Stable Cell Lines

Other Comments

The partial loss of function seen in Clic heterozygotes does not consistently alter negative geotaxis, indicting that the decrease in ethanol sensitivity seen in Clic mutants is independent of global improvements in negative geotaxis or climbing behavior.

(Bhandari et al., 2012)

Clic may function as a redox protein that confers resistance to oxidative stress.

(Berryman and Tanda, 2005)

Clic mutants created by P-element insertion have a 60-70% shorter lifespan and demonstrate a dosage-dependent hypersensitivity to oxidative stress.

(Berryman and Tanda, 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

"l(1)G0435" may affect "CG10997".

(Peter et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: Clic l(1)G0053

(Berryman, 2005.3.2)

Source for identity of: l(1)G0053 CG10997 l(1)G0472

(Peter et al., 2002)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG10997

(Schertel et al., 2013, Tsubouchi et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Littler et al., 2008, Legube et al., 2006, Berryman, 2005.3.2, Bianchi-Frias et al., 2004, Asha et al., 2003, Cooley et al., 2003.5, de Morais Guedes et al., 2003, Morin et al., 2001)

CLIC

(Littler et al., 2010)

DCLIC

(Berryman and Tanda, 2005)

DmCLIC

(Song et al., 2023, Ponnalagu et al., 2016, Littler et al., 2008)

clic

(Tsubouchi et al., 2012)

l(1)G0053

(Peter et al., 2002)

l(1)G0472

(Schäfer et al., 1999.12.2)

Name Synonyms

Chloride intracellular channel

(Bhandari et al., 2012, Tsubouchi et al., 2012, Berryman and Tanda, 2005)

Secondary FlyBase IDs

FBgn0040150

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32349

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VY78

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VY78

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VY78

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030529

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32349/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030529

FlyMine - An integrated database for Drosophila genomics

FBgn0030529

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10997

MARRVEL_MODEL - MARRVEL (model organism gene)

32349

PDB - An information portal to biological macromolecular structures

2YV7

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030529

DroID - A comprehensive database of gene and protein interactions.

FBgn0030529

DRSC - Results frm RNAi screens

FBgn0030529

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030529

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030529

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10997

Flygut - An atlas of the Drosophila adult midgut

FBgn0030529

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005408

MIST (protein-protein) - An integrated Molecular Interaction Database

32349

References (73)

The following external sites may use different assemblies or annotations than FlyBase.

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