FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ClicG0472
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General Information
Symbol
Dmel\ClicG0472
Species
D. melanogaster
Name
FlyBase ID
FBal0103721
Feature type
allele
Associated gene
Dmel\Clic
Associated Insertion(s)
P{lacW}ClicG0472
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.12.2)
Progenitor genotype
Associated Insertion(s)
P{lacW}ClicG0472
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ426897
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  central nervous system cancer
      modeled by dpnUAS.cUa
      (Francisco et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous female and hemizygous male ClicG0472 flies are lethal at 25[o]C. Heterozygous ClicG0472 females are fertile and appear morphologically normal and generally healthy.

      In an eRING assay to assess ethanol behavior, ClicG0472 heterozygous females maintain their negative geotaxis behavior for longer than controls, during exposure to ethanol, suggesting that these mutants have reduced sensitivity to the sedative effects of ethanol. ClicG0472 hemizygous males and homozygous females (reared at 20[o]C to improve viability) exhibit diminished ethanol sensitivity. In contrast to the effect on ethanol sensitivity, no significant effect on rapid ethanol tolerance is found.

      Climbing speed in negative geotaxis assays is indistinguishable in ClicG0472 heterozygotes compared to controls. Climbing latency is decreased in ClicG0472 heterozygotes compared to controls.

      (Bhandari et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.12.2)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ClicG0472
      (Francisco et al., 2020, Bhandari et al., 2012, Popodi et al., 2010-)
      l(1)G0053G0472
      l(1)G0472
      (Peter et al., 2002)
      l(1)G0472G0472
      (Schäfer et al., 1999.12.2)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)