FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ecoEY00297
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General Information
Symbol
Dmel\ecoEY00297
Species
D. melanogaster
Name
FlyBase ID
FBal0155348
Feature type
allele
Associated gene
Dmel\eco
Associated Insertion(s)
P{EPgy2}larkEY00297
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Williams et al., 2003)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}larkEY00297
    Cytology
    Description

    P-element insertion into the 5' UTR.

    (Williams et al., 2003)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous larval brains show an increased mitotic index (1.33) compared to wild type (1.04). 70% of the mitotic cells are in prometaphase/metaphase compared to 88% in wild type. 23% of anaphases show abnormalities, 29% of mitotic cells have overcondensed chromosomes and 36% of prometaphase/metaphase cells show precocious sister chromatid separation (PSCS). Hemizygous larval brains show a reduced mitotic index (0.75) compared to wild type (1.04). 74% of the mitotic cells are in prometaphase/metaphase compared to 88% in wild type. 31% of anaphases show abnormalities, 34% of mitotic cells have overcondensed chromosomes and 26% of prometaphase/metaphase cells show precocious sister chromatid separation (PSCS). Metaphase figures show high levels of aneuploidy. eco1/ecoEY00297 larval brains show a reduced mitotic index (0.80) compared to wild type (1.04). 78% of the mitotic cells are in prometaphase/metaphase compared to 88% in wild type. 19% of anaphases show abnormalities, 31% of mitotic cells have overcondensed chromosomes and 32% of prometaphase/metaphase cells show precocious sister chromatid separation (PSCS).

        (Williams et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        deco2
        (Williams et al., 2003)
        ecoEY00297
        Name Synonyms
        Secondary FlyBase IDs
          References (1)