FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cacTS3
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General Information
Symbol
Dmel\cacTS3
Species
D. melanogaster
Name
FlyBase ID
FBal0155528
Feature type
allele
Associated gene
Dmel\cac
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Rieckhof et al., 2003)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Using a negative geotaxis assay, the mean distance climbed is reduced by 14% in cacNT27 mutants compared with wild-type.

      Whole-cell calcium currents in typical cacTS3 mutant pupal neurons have smaller slow-inactivating components compared to wild-type. Slow-inactivating current density is reduced by 47% in cacTS3 mutants compared with wild-type neurons. This decrease in density is not due to a shift in voltage dependence because the current-density-voltage curves and the normalised conductance-voltage curves are similar.

      Addition of PLTXII (Plectreurys toxin II) further reduces the slow-inactivating current density found in cacTS3 mutant neurons. However, the fast-inactivating PLTII-resistant current is unaffected.

      (Gu et al., 2009)

      Mutant flies show a rapid onset of uncoordination, seizure-like activity and loss of motor control when placed at 38oC. The flies show a rapid recovery when returned to room temperature.

      (Rieckhof et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series (decreasing severity): cacNT27 > cacTS3 > cacTS4 > cacTS5.

      (Rieckhof et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dmca1ATS3
      (Rieckhof et al., 2003)
      TS3
      (Gu et al., 2009)
      cacTS3
      (Gu et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)