FlyBase Allele Report: Dmel\botv[510]

General Information

Symbol

Dmel\botv⁵¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0155557

Feature type

allele

Associated gene

Dmel\botv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Takei et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: P669L.

(Takei et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:19,132,205..19,132,205 [+]

Nucleotide change:

C19132205T

Amino acid change:

P669L | botv-PA

Reported amino acid change:

P669L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Takei et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neonatal diabetes mellitus

modeled by Hsap\INS^C96Y.UAS

(He et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage (with botv⁴²³)

(Takei et al., 2004)

some die during pupal stage (with botv⁴²³)

(Takei et al., 2004)

Phenotype Manifest In

eye | P-stage (with botv⁴²³)

(Takei et al., 2004)

imaginal disc | larval stage (with botv⁴²³)

(Takei et al., 2004)

leg | P-stage (with botv⁴²³)

(Takei et al., 2004)

wing | somatic clone

(Takei et al., 2004)

wing disc | larval stage (with botv⁴²³)

(Takei et al., 2004)

Detailed Description

Statement

Reference

botv⁴²³/botv⁵¹⁰ animals die as pupae with small eyes and legs. Third instar larvae have smaller discs than the wild type, and in particular, their wing discs are narrower in an anterior-posterior direction. Tissue is deleted within somatic clones of botv⁵¹⁰ homozygous cells in the adult wing.

(Takei et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

botv⁵¹⁰, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\INS^C96Y.UAS, Scer\GAL4^GMR.PF

(He et al., 2014)

NOT Enhancer of

Statement

Reference

botv⁵¹⁰/botv[+] is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

NOT Suppressor of

Statement

Reference

botv⁵¹⁰/botv[+] is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

botv⁵¹⁰, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\INS^C96Y.UAS, Scer\GAL4^GMR.PF

(He et al., 2014)

NOT Enhancer of

Statement

Reference

botv⁵¹⁰/botv[+] is a non-enhancer of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

NOT Suppressor of

Statement

Reference

botv⁵¹⁰/botv[+] is a non-suppressor of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Other

Statement

Reference

botv⁵¹⁰, ttv⁵²⁴ has wing disc | somatic clone phenotype

(Bischoff et al., 2013)

botv⁵¹⁰, ttv⁵²⁴ has cytoneme | larval stage phenotype

(Bischoff et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Unlike in controls, cytonemes do not cross over ttv⁵²⁴, botv⁵¹⁰ double mutant clones at the wing disc anterior compartment abutting the A-P compartment border, except if the cones are very narrow.

(Bischoff et al., 2013)

The commissural axon phenotype (failure to cross the midline) seen in embryos expressing Sema-1a^Scer\UAS.cYa under the control of Scer\GAL4^P52 in a Sema-1a^k13702 null background is not affected if the embryos are also heterozygous for botv⁵¹⁰.

(Cho et al., 2012)

Xenogenetic Interactions

Statement

Reference

One copy of botv⁵¹⁰ enhances the eye phenotype seen when Hsap\INS^{C96Y.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(He et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

botv⁵¹⁰

(Aguirre-Tamaral et al., 2022, Simon et al., 2021, He et al., 2014, Bischoff et al., 2013, Sekine et al., 2013, Cho et al., 2012, Ren et al., 2009)

botv_510

(He et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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