Amino acid replacement: K57R.
larval head, with bcd6
One copy of bcdK57R is not sufficient to rescue bcd6/bcd6 lethality (100%), with 69% of embryos exhibiting an unhatched phenotype. Of the hatched embryos, 50% exhibited larval head defects. Two copies of bcdK57R partially rescues bcd6/bcd6 lethality, with 25% of embryos failing to hatch. Of these that do hatch, 36% exhibit larval head defects such as reductions in the dorsal arm, dorsal bridge, and labrum, or moderate to strong defects such as the absence of discernable head skeletal structures and general disorganisation of the head. Approximately 10% of embryos lack head and thoracic structures entirely and contain a posterior duplication. One copy of bcdS35T, with one copy of bcdK57R in a bcd6 homozygote background partially rescues the bcd6 embryonic lethality phenotype, with 31% of embryos remaining unhatched. Of those that do hatch, 26% exhibited larval head defects.
(with bcdS35T) Partially rescues: bcd6