FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bcdK57R
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General Information
Symbol
Dmel\bcdK57R
Species
D. melanogaster
Name
FlyBase ID
FBal0155590
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Amino acid replacement: K57R.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of bcdK57R is not sufficient to rescue bcd6/bcd6 lethality (100%), with 69% of embryos exhibiting an unhatched phenotype. Of the hatched embryos, 50% exhibited larval head defects. Two copies of bcdK57R partially rescues bcd6/bcd6 lethality, with 25% of embryos failing to hatch. Of these that do hatch, 36% exhibit larval head defects such as reductions in the dorsal arm, dorsal bridge, and labrum, or moderate to strong defects such as the absence of discernable head skeletal structures and general disorganisation of the head. Approximately 10% of embryos lack head and thoracic structures entirely and contain a posterior duplication. One copy of bcdS35T, with one copy of bcdK57R in a bcd6 homozygote background partially rescues the bcd6 embryonic lethality phenotype, with 31% of embryos remaining unhatched. Of those that do hatch, 26% exhibited larval head defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

(with bcdS35T) Partially rescues: bcd6

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)