FlyBase Allele Report: Dmel\bcd[6]

General Information

Symbol

Dmel\bcd⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0001080

Feature type

allele

Associated gene

Dmel\bcd

Associated Insertion(s)

Carried in Construct

Also Known As

bcd^E1

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Schroder and Sander, 1993, Gavis and Lehmann, 1992, Struhl et al., 1992, Schroder et al., 1988)

loss of function allele

(Eldon and Pirrotta, 1991, Kraut and Levine, 1991)

Mutagen

ethyl methanesulfonate

(Kraut and Levine, 1991, Berleth et al., 1988, Driever and Nusslein-Volhard, 1988, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid interval 151 to 207 deleted, followed by a frame shift.

(Rivera-Pomar et al., 1996)

Small deletion.

(Kraut and Levine, 1991)

Large deletion.

(Driever et al., 1989)

Deletion of nucleotides 2482 to 2650 and an insertion of nucleotides TA, corresponding deletion of amino acids 156 to 494 that are replaced by 55 out of frame amino acids.

(Struhl et al., 1989)

Small deletion of 180bp within the bcd homeobox domain.

(Berleth et al., 1988)

Small deletion within the bcd coding region.

(Driever and Nusslein-Volhard, 1988)

2482-2650 deleted + TA inserted; frameshift --> 55 out-of-frame amino acids replacing amino acids 156-494, including homeodomain

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:6,758,037..6,758,205 [-]

Comment:

A deletion of 169 bases and insertion of the bases TA. The net result is that bcd amino acids 156-494 are replaced by 55 out-of-frame amino acids.

Inserted_sequence:

(Struhl et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Struhl et al., 1989)

lethal - all die during embryonic stage

(Cho et al., 2005, Lebrecht et al., 2005)

lethal - all die during embryonic stage, with bcd^K57R

(Lebrecht et al., 2005)

lethal - all die during embryonic stage, with bcd^S35T

(Lebrecht et al., 2005)

lethal - all die during embryonic stage | maternal effect

lethal - all die during embryonic stage | recessive

(Salles et al., 1994, Driever et al., 1989)

partially lethal - majority die, with bcd^Y66A.nanos

(Cho et al., 2005)

partially lethal - majority die, with bcd^Y73R.nanos

(Cho et al., 2005)

some die during embryonic stage

(Cho et al., 2005, Lebrecht et al., 2005)

some die during embryonic stage, with bcd^K57R

(Lebrecht et al., 2005)

some die during embryonic stage, with bcd^S35T

(Lebrecht et al., 2005)

some die during embryonic stage, with bcd^Y66A.nanos

(Cho et al., 2005)

some die during embryonic stage, with bcd^Y73R.nanos

(Cho et al., 2005)

some die during embryonic stage | maternal effect

some die during embryonic stage | recessive

(Salles et al., 1994, Driever et al., 1989)

Phenotype Manifest In

abdomen

(Schroder and Sander, 1993)

embryo | anterior | maternal effect

(Frohnhofer and Nusslein-Volhard, 1987)

embryo | anterior | maternal effect (with bcd²)

(Frohnhofer and Nusslein-Volhard, 1987)

embryo | anterior | maternal effect (with bcd⁷)

(Frohnhofer and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle

(Cho et al., 2005, Niessing et al., 2002, Bellaiche et al., 1996)

embryonic/first instar larval cuticle, with bcd^Y66A.nanos

(Cho et al., 2005)

embryonic/first instar larval cuticle, with bcd^Y73R.nanos

(Cho et al., 2005)

embryonic/larval posterior spiracle | ectopic (with bcd¹)

(Shaw et al., 2002)

embryonic/larval salivary gland | embryonic stage

(Namba et al., 1997)

embryonic/larval spiracle

(Bellaiche et al., 1996)

embryonic abdominal segment 2

(Wimmer et al., 2000)

embryonic abdominal segment 4

(Wimmer et al., 2000)

embryonic head

(Kennerdell et al., 2002, Salles et al., 1994, Sugiyama and Okada, 1990)

embryonic head (with bcd¹)

(Shaw et al., 2002)

embryonic head | maternal effect

(Frohnhofer and Nusslein-Volhard, 1987)

embryonic head | maternal effect (with bcd⁷)

(Frohnhofer and Nusslein-Volhard, 1987)

embryonic head segment

(Wimmer et al., 2000)

embryonic mesothoracic segment

(Wimmer et al., 2000)

embryonic metathoracic segment

(Wimmer et al., 2000)

embryonic prothoracic segment

(Wimmer et al., 2000)

embryonic thoracic segment

(Kennerdell et al., 2002)

embryonic thorax

(Salles et al., 1994, Schroder and Sander, 1993, Sugiyama and Okada, 1990)

embryonic thorax (with bcd¹)

(Shaw et al., 2002)

embryonic thorax | maternal effect

(Frohnhofer and Nusslein-Volhard, 1987)

embryonic thorax | maternal effect (with bcd⁷)

(Frohnhofer and Nusslein-Volhard, 1987)

filzkorper

(Schroder and Sander, 1993)

larval head

(Gamberi et al., 2002)

larval head, with bcd^+t8.7

(Lebrecht et al., 2005)

larval head, with bcd^K57R

(Lebrecht et al., 2005)

larval head, with bcd^S35T

(Lebrecht et al., 2005)

mitotic domain 1 | extended germ band stage

(Irvine and Wieschaus, 1994)

ocular segment

(Kennerdell et al., 2002, Lehmann, 1988)

primordial germ cell

(Lasko and Ashburner, 1990)

telson

(Schroder and Sander, 1993)

telson | ectopic

(Kennerdell et al., 2002)

terminalia | ectopic

(Wimmer et al., 2000)

Detailed Description

Statement

Reference

bcd⁶ homozygotes exhibit embryonic lethality, with 100% of embryos failing to hatch. bcd⁶ heterozygotes exhibit 4% embryonic lethality, which is similar to controls (8%). One copy of bcd^+t8.7 is sufficient to rescue bcd⁶/bcd⁶ lethality (100%) to levels similar to that of bcd⁶/+ embryos (8% compared to 4% unhatched in bcd⁶ heterozygotes). Of those that did hatch, 3% exhibit larval head defects. One copy of bcd^K57R is not sufficient to rescue bcd⁶/bcd⁶ lethality (100%), with 69% of embryos exhibiting an unhatched phenotype. Of the hatched embryos, 50% exhibited larval head defects. Two copies of bcd^K57R partially rescues bcd⁶/bcd⁶ lethality, with 25% of embryos failing to hatch. Of these that do hatch, 36% exhibit larval head defects such as reductions in the dorsal arm, dorsal bridge, and labrum, or moderate to strong defects such as the absence of discernable head skeletal structures and general disorganisation of the head. Approximately 10% of embryos lack head and thoracic structures entirely and contain a posterior duplication. One copy of bcd^S35T is not sufficient to rescue bcd⁶/bcd⁶ lethality (100%), with 37% of embryos exhibiting an unhatched phenotype. Of these that do hatch, 11% exhibit larval head defects. Two copies of bcd^S35T rescues bcd⁶/bcd⁶ lethality (3% compared to 4% in bcd⁶ heterozygotes), with 3% of embryos failing to hatch. Of these that do hatch, none exhibit larval head defects. One copy of bcd^S35T, with one copy of bcd^K57R in a bcd⁶ homozygote background partially rescues the bcd⁶ embryonic lethality phenotype, with 31% of embryos remaining unhatched. Of those that do hatch, 26% exhibited larval head defects.

(Lebrecht et al., 2005)

bcd⁶ embryos have no head structures. The anterior structures resemble posterior ones.

(Gamberi et al., 2002)

Embryos derived from homozygous females lack head and thoracic segments, and the acron is partially or fully transformed into telson.

(Kennerdell et al., 2002)

Embryos derived from bcd⁶/bcd¹ females lack all head and thoracic structures and have a duplicated set of posterior spiracles at the anterior end.

(Shaw et al., 2002)

Embryos derived from homozygous bcd⁶ mothers show head and thorax replaced by tail structures. Abdominal segments 2 and 4 are missing.

(Wimmer et al., 2000)

Embryos derived from homozygous females lack all head and thorax segments and some abdominal segments. They have a second telson at the anterior end. The ability of bcd^ΔQAC to rescue embryos derived from bcd⁶ females is not affected by either Taf6^XS-922 or Taf4^S-466.

(Schaeffer et al., 1999)

Embryos derived from heterozygous females have normal cuticles. Larvae derived from heterozygous females have salivary glands with a significantly reduced number of cells compared to wild-type. There is an increase in cell death in the expanded trunk domain of embryos derived from heterozygous females compared to embryos derived from wild-type females.

(Namba et al., 1997)

Cuticle phenotype, additional spiracles develop at the anterior.

(Bellaiche et al., 1996)

Does not prevent the posterior localization of G-iα65A protein.

(Wolfgang and Forte, 1995)

bcd, nos double mutants show reduced rate of germ band extension, and reduced cell intercalation.

(Irvine and Wieschaus, 1994)

Anterior structures of homozygous embryos are not formed.

(Salles et al., 1994)

Embryos from homozygous females produce only abdomen and telson, with a second telson and filzkorper patches formed at the anterior end.

(Schroder and Sander, 1993)

bcd⁶, tsl³ embryos, which lack both anterior and terminal gene functions, show no tll expression at either pole. In bcd⁶ embryos tll transcription is activated at both poles in two terminal caps, the caps are larger than wild type caps. The presence of the bcd has a negative effect on the anterior cap of tll expression so tll expression is equal in the caps.

(Pignoni et al., 1992)

Anterior gt expression domain is absent, the posterior domain is correctly initiated.

(Kraut and Levine, 1991)

The development of anterior structures can be induced by the injection of bcd^TN3 mRNA into the anterior tip of the embryos. P{bcdTN3} expands and shifts the bcd expression domain slightly more anterior towards the gnathal and thoracic regions.

(Driever et al., 1990)

Embryos derived from hb¹⁵ bcd⁶ females show a mirror image duplication of abdominal segments, centered around A6. Embryos derived from hb¹⁵ bcd⁶ females, and also zygotically mutant for hb⁸ show a mirror image duplication of abdominal segments, centered around A6, and segments A7 and A8 are fused.

(Hulskamp et al., 1990)

Embryonic pole cells do not coalesce correctly into the gonads.

(Lasko and Ashburner, 1990)

Deletion of head and most of the thorax, replaced by a telson duplicated in the anterior. Transplantation of posterior cytoplasm from wild type embryos into the anterior portion induced posterior segments of reversed polarity in addition to the anteriorly duplicated telson.

(Sugiyama and Okada, 1990)

The acron is replaced by a second telson in embryos derived from homozygous females.

(Lehmann, 1988)

Inverted duplication of the posterior hb domain.

(Schroder et al., 1988)

The head and thorax are replaced by a duplicated telson in embryos derived from homozygous females. Embryos derived from bcd²/bcd⁶ females have anterior defects. Embryos derived from bcd⁶/bcd⁷ females show some development of at least thoracic and frequently head structures when injected at the anterior tip with cytoplasm taken from the anterior tip of wild-type embryos.

(Frohnhofer and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bcd⁶/bcd[+] is an enhancer of lethal | embryonic stage | maternal effect phenotype of Df(2R)Drl^rv25/bin3^KG00599

(Singh et al., 2011)

bcd⁶/bcd[+] is an enhancer of lethal | embryonic stage | maternal effect phenotype of bin3^4-7/bin3^2-7

(Singh et al., 2011)

bcd⁶ is an enhancer of lethal | embryonic stage | recessive phenotype of Scer\GAL4^{GCN4.nanos.bcd3'UTR}, hb^UAS.cWa

(Janody et al., 2000)

Other

Statement

Reference

bcd⁶, nanos^L7, tsl³ has abnormal cell polarity | maternal effect | gastrula stage phenotype

(Zallen and Wieschaus, 2004)

Polr2B^wimp, bcd⁶ has lethal | maternal effect phenotype

(Parkhurst and Ish-Horowicz, 1991)

Phenotype Manifest In

Enhanced by

Statement

Reference

Bin1^R7-18, bcd⁶ has embryonic head | maternal effect phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶

(Singh et al., 2005)

NOT Enhanced by

Statement

Reference

bcd⁶ has phenotype, non-enhanceable by sra⁶⁸⁷

(Singh et al., 2005)

bcd^ΔQAC, bcd⁶ has embryo phenotype, non-enhanceable by Taf6^XS-922

(Schaeffer et al., 1999)

bcd^ΔQAC, bcd⁶ has embryo phenotype, non-enhanceable by Taf4^S-466

(Schaeffer et al., 1999)

Suppressed by

Statement

Reference

bcd⁶ has embryo | maternal effect phenotype, suppressible by tsl^CBB.bcd/osk⁶/tsl^PZRev32

(Stevens et al., 2003)

bcd⁶/bcd¹ has embryonic/larval posterior spiracle | ectopic phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

bcd⁶/bcd¹ has embryonic thorax phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

bcd⁶/bcd¹ has embryonic head phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

bcd⁶ has embryonic prothoracic segment phenotype, suppressible by Scer\GAL4^{GCN4.nanos.bcd3'UTR}/hb^UAS.cWa

(Wimmer et al., 2000)

bcd⁶ has embryonic mesothoracic segment phenotype, suppressible by Scer\GAL4^{GCN4.nanos.bcd3'UTR}/hb^UAS.cWa

(Wimmer et al., 2000)

bcd⁶ has embryonic metathoracic segment phenotype, suppressible by Scer\GAL4^{GCN4.nanos.bcd3'UTR}/hb^UAS.cWa

(Wimmer et al., 2000)

NOT suppressed by

Statement

Reference

bcd^ΔQAC, bcd⁶ has embryo phenotype, non-suppressible by Taf6^XS-922

(Schaeffer et al., 1999)

bcd^ΔQAC, bcd⁶ has embryo phenotype, non-suppressible by Taf4^S-466

(Schaeffer et al., 1999)

Suppressor of

Statement

Reference

tsl^CBB.bcd, bcd⁶, tsl^PZRev32 is a suppressor of embryo | maternal effect phenotype of osk⁶

(Stevens et al., 2003)

Other

Statement

Reference

bcd⁶, tsl¹ has embryonic/first instar larval cuticle phenotype

(Brent et al., 2007)

Bin1^R7-18, bcd⁶ has embryonic head | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has dorsal arm of apodeme of rostrum-haustellum joint | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has epipharyngeal sclerite | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has embryonic/larval mouth | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has dorsal bridge | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has median tooth | maternal effect phenotype

(Singh et al., 2005)

Bin1^R7-18, bcd⁶ has ventroposterior arm of apodeme of rostrum-haustellum joint | maternal effect phenotype

(Singh et al., 2005)

bcd⁶, osk⁶, tsl^PZRev32 has embryo | maternal effect phenotype

(Stevens et al., 2003)

bcd⁶, nanos^L7, tsl³ has embryo | embryonic stage 4 phenotype

(Blankenship and Wieschaus, 2001)

bcd^ΔA, bcd⁶, tsl¹ has embryo | posterior phenotype

(Schaeffer et al., 2000)

bcd⁶, nanos^L7 has telson phenotype

(Lehmann and Frohnhofer, 1989)

bcd⁶, nanos^L7, tll¹ has epidermis phenotype

(Lehmann and Frohnhofer, 1989)

bcd⁶, nanos^L7, tll¹ has telson phenotype

(Lehmann and Frohnhofer, 1989)

bcd⁶, nanos^L7, tsl³ has epidermis phenotype

(Lehmann and Frohnhofer, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

The anterior fatemap shift caused by maternal bcd dosage reduction (in bcd⁶ heterozygotes) is suppressed partially by eliminating fsd maternally (through a fsd^KG02393 background).

(Liu and Ma, 2011)

The defects seen in the progeny of bin3^4-7/bin3^2-7 females mated to bin3^KG00599/Df(2R)Drl^rv25 males and in the reciprocal cross are enhanced by a maternal copy of bcd⁶/+.

(Singh et al., 2011)

Anisotropic epithelial constriction still occurs in bcd⁶ nos^L7 tsl³ triple mutant embryos that lack anterior-posterior polarity.

(Martin et al., 2010)

9% of bcd⁶/Bin1^R7-18 double heterozygotes die as unhatched embryos with serious head defects including missing mouth parts. These larvae are missing labral structures most frequently the labrum itself and the epistomal sclerite. In some cases the dorsal bridge, dorsal bridge, dorsal and ventral arms, and post pharyngeal wall are absent or reduced in size.

(Singh et al., 2005)

Anterior-posterior polarization of cells in the extending germband is disrupted in embryos from bcd⁶ nos^L7 tsl³ homozygous mothers.

(Zallen and Wieschaus, 2004)

Embryos produced by bcd⁶, osk⁶ and tsl^PZRev32 mutant mothers lack all anterior posterior patterning. This phenotype is partially rescued by the addition of tsl^CBB.bcd, leading to embryos that differentiate filzkorper material, at one or both poles.

(Stevens et al., 2003)

Embryos derived from bcd⁶ nos^L7 tsl³ triple mutant females have uniform yolk stalk diameters during cellularisation (in contrast to wild type where there are three domains of varying yolk stalk diameter along the anterior-posterior axis of the embryo). The shallow cellularisation front of the anterior domain and the greater depth of the pre-cephalic furrow domain are also lost. Other aspects of cellularisation are normal in these embryos. Nuclear spacing is uniform along the anterior-posterior axis in embryos derived from bcd⁶ nos^L7 tsl³ triple mutant females (in contrast to wild type where there is an anterior domain of lower nuclear density). The larger diameter of the actin caps seen in the anterior of the wild-type embryo in cycle 11 and 12 is not seen in embryos derived from bcd⁶ nos^L7 tsl³ triple mutant females.

(Blankenship and Wieschaus, 2001)

The embryonic lethality seen in embryos expressing hb^Scer\UAS.cWa under the control of Scer\GAL4^{nos.bcd3'UTR.T:Scer\GCN4} (where Scer\GAL4^{nos.bcd3'UTR.T:Scer\GCN4} is provided maternally) is increased if they are derived from females carrying one copy of bcd⁶.

(Janody et al., 2000)

The addition of bcd^ΔA to tsl¹, bcd⁶ embryos rescues the anterior part of the tsl¹ mutant phenotype (rescuing the labrum and dorsal bridge) as well as rescuing the bcd⁶ mutant phenotype. This results in embryos with a posterior terminal mutant phenotype only.

The addition of tsl¹ does not effect the ability of bcd^ΔQAC to rescue the bcd⁶ phenotype. The addition of bcd^ΔA to tsl¹, bcd⁶ embryos rescues the terminal system phenotype seen in these animals.

(Schaeffer et al., 2000)

Embryos derived from homozygous bcd⁶ mothers carrying four copies of Scer\GAL4^{nos.bcd3'UTR.T:Scer\GCN4} and fathers carrying hb^Scer\UAS.cWa homozygously show suppression of anterior tail structures and thoracic structures are rescued to variable extent, up to a complete rescue of T2 and T3.

(Wimmer et al., 2000)

Mutant phenotype of bcd mutant embryos is enhanced by hb^bcd.3UTR, due to ectopic activation of gt. Mutant phenotype of bcd, tsl double mutants is partially rescued by hb^bcd.3UTR.

(Schulz and Tautz, 1994)

In contrast, cytoplasm taken from the anterior tip of embryos derived from exu¹/exu² females shows barely detectable rescuing activity when injected into the anterior tip of embryos derived from bcd⁶/bcd⁷ females. Cytoplasm taken from the anterior tip of embryos derived from swa¹/swa² females also shows reduced rescuing activity compared to wild-type cytoplasm when injected into the anterior tip of embryos derived from bcd⁶/bcd⁷ females. exu¹ does not alter the phenotype of embryos derived from bcd⁶/bcd⁷ females.

(Klingler and Gergen, 1993)

bcd⁶ nos^L7 embryos exhibit two telsons in mirror image. Injection of wild type posterior pole plasm induces formation of two mirror image abdomens. bcd⁶ nos^L7 tll¹ embryos exhibit two telsons in mirror image. Injection of wild type posterior pole plasm induces formation of two mirror image abdomens. bcd⁶ nos^L7 tsl³ embryos develop a cuticle but no segmental pattern. Injection of wild type posterior pole plasm induces formation of anterior abdominal segments towards the end of the embryo.

(Lehmann and Frohnhofer, 1989)

Xenogenetic Interactions

Statement

Reference

Mdoa\bcd^bcd.1 partially rescues the defects seen in embryos derived from bcd⁶/bcd¹ females, with the degree of rescue depending on the Mdoa\bcd^bcd.1 line used. In the strongest rescuing line, complete rescue is seen in a small proportion of embryos, as shown by the presence of all three thoracic segments, a complete head skeleton and other anterior structures such as the mouthhooks and labrum. 7.4% of embryos can develop into fully fertile adults, but most embryos show no rescue.

(Shaw et al., 2002)

Complementation and Rescue Data

Rescued by

bcd⁶ is rescued by bcd^6xTag:MS2

(Weil et al., 2006)

bcd⁶ is rescued by bcd^nanos.PC

(Cho et al., 2005)

bcd⁶ is rescued by bcd^Y68A.nanos

(Cho et al., 2005)

bcd⁶ is rescued by bcd^Y72A.nanos

(Cho et al., 2005)

bcd⁶ is rescued by bcd^+t8.7

(Lebrecht et al., 2005)

bcd⁶ is rescued by bcd^+t6

(Gamberi et al., 2002)

bcd⁶ is rescued by bcd^{1-489AR.nanos}

(Niessing et al., 2002)

bcd⁶ is rescued by bcd^1-489.nanos

(Niessing et al., 2002)

bcd⁶ is rescued by bcd^K57A

(Niessing et al., 2000)

bcd⁶ is rescued by bcd^ΔA

(Schaeffer et al., 2000)

bcd⁶ is rescued by bcd^ΔQAC

(Schaeffer et al., 2000)

bcd⁶ is rescued by bcd^+tWT

(Schaeffer et al., 2000)

bcd⁶ is rescued by bcd^5ala.nanos

(Niessing et al., 1999)

bcd⁶ is rescued by bcd^ΔA

(Schaeffer et al., 1999)

bcd⁶ is rescued by bcd^ΔQAC

(Schaeffer et al., 1999)

bcd⁶ is rescued by bcd^+tWT

(Schaeffer et al., 1999)

bcd⁶ is rescued by bcd^ΔQ

(Schaeffer et al., 1999)

bcd⁶ is rescued by bcd^ΔQA

(Schaeffer et al., 1999)

bcd⁶ is rescued by bcd^ΔPRT

(Bellaiche et al., 1996)

bcd⁶ is rescued by bcd^+t8.7

(Bellaiche et al., 1996)

bcd⁶ is rescued by bcd^+t8

(Schulz and Tautz, 1995)

bcd⁶ is rescued by bcd^Δ17

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ9

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ3-5

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ8

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ1

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ4

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ6

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ10

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ2

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ3

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ20

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ5

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ14S

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ15

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ13

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^Δ12

(MacDonald et al., 1993)

bcd⁶ is rescued by bcd^TN3

(Driever et al., 1990)

bcd⁶ is rescued by bcd^+t8

(Struhl et al., 1989)

bcd⁶ is rescued by bcd^+t8.7

(Berleth et al., 1988)

Partially rescued by

bcd⁶ is partially rescued by bcd^Y66A.nanos

(Cho et al., 2005)

bcd⁶ is partially rescued by bcd^Y73R.nanos

(Cho et al., 2005)

bcd⁶ is partially rescued by bcd^S35T

(Lebrecht et al., 2005)

bcd⁶ is partially rescued by bcd^K57R

(Lebrecht et al., 2005)

bcd⁶ is partially rescued by bcd^NRE1

(Gamberi et al., 2002)

bcd⁶ is partially rescued by bcd^NRE2

(Gamberi et al., 2002)

bcd⁶ is partially rescued by bcd^R54A

(Niessing et al., 2000)

bcd⁶ is partially rescued by bcd^ΔQC

(Schaeffer et al., 1999)

bcd⁶ is partially rescued by bcd^ΔC

(Schaeffer et al., 1999)

bcd⁶ is partially rescued by bcd^ΔAC

(Schaeffer et al., 1999)

bcd⁶ is partially rescued by bcd^B6

(Bellaiche et al., 1996)

bcd⁶ is partially rescued by bcd^Δ18

(MacDonald et al., 1993)

bcd⁶ is partially rescued by bcd^Δ16

(MacDonald et al., 1993)

bcd⁶ is partially rescued by bcd^Δ11

(MacDonald et al., 1993)

bcd⁶ is partially rescued by bcd^Δ19

(MacDonald et al., 1993)

bcd⁶ is partially rescued by bcd^Δ7

(MacDonald et al., 1993)

Not rescued by

bcd⁶ is not rescued by bcd^{1-202AR.nanos}

(Niessing et al., 2002)

bcd⁶ is not rescued by bcd^77-202.nanos

(Niessing et al., 2002)

bcd⁶ is not rescued by bcd^89-202.nanos

(Niessing et al., 2002)

bcd⁶ is not rescued by bcd^N51A

(Niessing et al., 2000)

bcd⁶ is not rescued by bcd^R55A

(Niessing et al., 2000)

bcd⁶ is not rescued by bcd^R53A

(Niessing et al., 2000)

bcd⁶ is not rescued by bcd^B42

(Bellaiche et al., 1996)

bcd⁶ is not rescued by bcd^2-74.G4DBD

(Bellaiche et al., 1996)

bcd⁶ is not rescued by bcd^2-94.G4DBD

(Bellaiche et al., 1996)

bcd⁶ is not rescued by bcd^Δ14

(MacDonald et al., 1993)

Comments

bcd^T:MS2\MCP alone or in combination with either MS2\MCP::Avic\GFP^Hsp83.PF or MS2\MCP::Avic\GFP^{Hsp83.T:Disc\RFP} completely rescues the bcd⁶ mutant phenotype.

(Weil et al., 2006)

bcd^ΔQAC rescues the bcd mutant phenotype of bcd⁶ tsl¹ double mutant embryos, resulting in a tsl single mutant phenotype.

bcd^ΔA rescues the bcd mutant phenotype of bcd⁶ tsl¹ double mutant embryos.

(Schaeffer et al., 2000)

Mutant phenotype cannot be rescued by bcd^T:Ecol\B42 but four copies of bcd^T:Ecol\B6 can rescue the thorax and part of the head. can rescue the thorax and part of the head.

(Bellaiche et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (8)

Bloomington

95072

w^*; PBac{αTub67C-mCh-bcd-LEXY(FRT.bcd3'UTR)sqh3'UTR}VK00033 bcd⁶/TM3, Sb¹

95071

w^*; PBac{αTub67C-iRFP713-bcd-LEXY(FRT.bcd3'UTR)sqh3'UTR}VK00033 bcd⁶/TM3, Sb¹

3630

Diap1^th-1 st¹ kni^ri-1 bcd⁶ rn^roe-1 p^p/TM3, Sb¹

29018

P{EGFP-bcd}1, y¹ w¹¹¹⁸; Diap1^th-1 st¹ kni^ri-1 bcd⁶ rn^roe-1 p^p

95110

w^*; PBac{αTub67C-bcd-LEXY(FRT.bcd3'UTR)sqh3'UTR}VK00033 bcd⁶ nanos^BN e¹ tsl⁴/TM3, Sb¹

95109

w^*; PBac{αTub67C-iRFP713-bcd-LEXY(FRT.bcd3'UTR)sqh3'UTR}VK00033 bcd⁶ nanos^BN e¹ tsl⁴/TM3, Sb¹

Kyoto

106945

st¹ kni^ri-1 bcd⁶ rn^roe-1 p^p nanos^L7 e¹/TM3, Sb¹ Ser¹

106943

Diap1^th-1 st¹ kni^ri-1 bcd⁶ rn^roe-1 p^p e¹ tsl¹/TM6C, Sb¹ Tb¹

Notes on Origin

Discoverer

Comments

Strong bcd allele.

(Driever and Nusslein-Volhard, 1988)

hb protein expression in early bcd⁶ mutant embryos has been studied.

(Tautz, 1988)

Anterior cytoplasm from embryos derived from bcd⁶ females can rescue both anterior and posterior defects when transplanted into the anterior or posterior end respectively of embryos derived from tor⁴ females.

(Sugiyama and Okada, 1990)

Phenotype can be rescued (to varying extents) by injection of egg cytoplasm from D.melanogaster, D.hydei, D.mercatorum, D.pinicola, D.polychaeta, D.pseudoobscura.pseudoobscura, D.virilis, Musca, Lucilia, Phormia and Megaselia, but not rescued by injection of egg cytoplasm by Calliphora or A.mellifera.

(Schroder and Sander, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Bcd^E1

(Garcia et al., 2013)

(Struhl et al., 1992)

bcd E¹

(Jacob et al., 1991)

bcd⁶

(Wharton et al., 2018, Tadros et al., 2007)

bcd^E1

(Athilingam et al., 2024, Baumgartner, 2024, Fernandes et al., 2022, Singh et al., 2022, Huang et al., 2020, Yang et al., 2020, Datta et al., 2018, Durrieu et al., 2018, Hannon et al., 2017, Suresh et al., 2017, Liu and Ma, 2015, Cheung et al., 2014, Spahn et al., 2014, Liu and Ma, 2013, Liu et al., 2013, Liu et al., 2013, Lucas et al., 2013, Cheung et al., 2011, Little et al., 2011, Liu and Ma, 2011, Singh et al., 2011, Löhr et al., 2009, Gregor et al., 2008, He et al., 2008, Lopes et al., 2008, Brent et al., 2007, Gregor et al., 2007, Weil et al., 2006, Wratten et al., 2006, Cho et al., 2005, Lebrecht et al., 2005, Singh et al., 2005, Werz et al., 2005, Riede, 2004, Zallen and Wieschaus, 2004, Nibu et al., 2003, Gamberi et al., 2002, Houchmandzadeh et al., 2002, Kennerdell et al., 2002, Niessing et al., 2002, Shaw et al., 2002, Blankenship and Wieschaus, 2001, Hartmann et al., 2001, Janody et al., 2001, Johnstone and Lasko, 2001, Janody et al., 2000, Janody et al., 2000, Niessing et al., 2000, Schaeffer et al., 2000, Wimmer et al., 2000, Crozatier et al., 1999, Niessing et al., 1999, Schaeffer et al., 1999, Tsai et al., 1998, Van Doren et al., 1998, Wolff et al., 1998, Bonneton et al., 1997, Greenwood and Struhl, 1997, Kuhnlein et al., 1997, La Rosee et al., 1997, Namba et al., 1997, Bellaiche et al., 1996, Dahanukar and Wharton, 1996, Dubnau and Struhl, 1996, Klingler et al., 1996, Reuter et al., 1996, Rivera-Pomar et al., 1996, Small et al., 1996, Hacker et al., 1995, Mohler, 1995, Rivera-Pomar et al., 1995, Schulz and Tautz, 1995, Wimmer et al., 1995, Wolfgang and Forte, 1995, Edgar et al., 1994, Frommer et al., 1994, Hanes et al., 1994, Hartmann et al., 1994, Irvine and Wieschaus, 1994, Jongens et al., 1994, Pelegri and Lehmann, 1994, Reuter and Leptin, 1994, Rothe et al., 1994, Salles et al., 1994, Schulz and Tautz, 1994, Simpson-Brose et al., 1994, Bardsley et al., 1993, Ding et al., 1993, Driever, 1993, Klingler and Gergen, 1993, Schroder and Sander, 1993, Gavis and Lehmann, 1992, Hoch et al., 1992, Pignoni et al., 1992, Eldon and Pirrotta, 1991, Hoch et al., 1991, Kraut and Levine, 1991, Parkhurst and Ish-Horowicz, 1991, Riddihough and Ish-Horowicz, 1991, Driever et al., 1990, Finkelstein and Perrimon, 1990, Grau and Gutzeit, 1990, Hulskamp et al., 1990, Jack and McGinnis, 1990, Lasko and Ashburner, 1990, Sugiyama and Okada, 1990, Sugiyama and Okada, 1990, Driever et al., 1989, Driever et al., 1989, Hooper et al., 1989, Lehmann and Frohnhofer, 1989, Struhl et al., 1989, Berleth et al., 1988, Driever and Nusslein-Volhard, 1988, Lehmann, 1988, Schroder et al., 1988, Tautz, 1988, Frohnhofer and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987)

bcd^E6

(Liang et al., 2012)

bcdE1

(Schaeffer et al., 1998, Schaeffer et al., 1998, Crozatier et al., 1996)

Name Synonyms

bicoidE1

(Martin et al., 2010)

Secondary FlyBase IDs

References (136)

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