FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bcdS35T
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General Information
Symbol
Dmel\bcdS35T
Species
D. melanogaster
Name
FlyBase ID
FBal0155586
Feature type
allele
Associated gene
Dmel\bcd
Associated Insertion(s)
Carried in Construct
P{bcd.S35T}
Key Links
Transgenic product class
missense_variant
(Lebrecht et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lebrecht et al., 2005)
Mutagen
in vitro construct
(Lebrecht et al., 2005)
Progenitor genotype
bcd+t8.7
(Lebrecht et al., 2005)
Carried in construct
P{bcd.S35T}
Cytology
Description

Amino acid replacement: S35T.

(Lebrecht et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
bcd
Encoded product / tool
bcd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of bcdS35T is not sufficient to rescue bcd6/bcd6 lethality (100%), with 37% of embryos exhibiting an unhatched phenotype. Of these that do hatch, 11% exhibit larval head defects. Two copies of bcdS35T rescues bcd6/bcd6 lethality (3% compared to 4% in bcd6 heterozygotes), with 3% of embryos failing to hatch. Of these that do hatch, none exhibit larval head defects. One copy of bcdS35T, with one copy of bcdK57R in a bcd6 homozygote background partially rescues the bcd6 embryonic lethality phenotype, with 31% of embryos remaining unhatched. Of those that do hatch, 26% exhibited larval head defects.

      (Lebrecht et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      bcdS35T partially rescues bcd6

      (Lebrecht et al., 2005)
      Comments

      (with bcdK57R) Partially rescues: bcd6

      (Lebrecht et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      bcdS35T
      Name Synonyms
      Secondary FlyBase IDs
        References (2)