FlyBase Allele Report: Dmel\bcd[1]

General Information

Symbol

Dmel\bcd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001075

Feature type

allele

Associated gene

Dmel\bcd

Associated Insertion(s)

Carried in Construct

Also Known As

bcd⁰⁸⁵

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Driever and Nusslein-Volhard, 1988)

Mutagen

ethyl methanesulfonate

(Driever and Nusslein-Volhard, 1988, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Truncates the protein after amino acid 187 and removes several distinct C-terminal domains (including the RRM, the opa repeat and most of the Ser Thr-rich sequence).

(Dubnau and Struhl, 1996)

Stop codon at amino acid position 179.

(Rivera-Pomar et al., 1996)

Amino acid replacement: Q184term.

(Struhl et al., 1989)

Nucleotide substitution: C2564T.

(Struhl et al., 1989)

The mutation is 28 amino acids downstream of the homeobox.

(Struhl et al., 1989)

Truncated protein.

(Driever and Nusslein-Volhard, 1988)

2564 C --> T; 184 gln --> amber

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,758,123..6,758,123 [-]

Nucleotide change:

C6758123T

Reported nucleotide change:

C2564T

Amino acid change:

Q179term | bcd-PD; Q108term | bcd-PE; Q103term | bcd-PF; Q184term | bcd-PG

Reported amino acid change:

Q184term

(Struhl et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect

some die during embryonic stage | maternal effect

Phenotype Manifest In

embryonic/larval posterior spiracle | ectopic (with bcd⁶)

(Shaw et al., 2002)

embryonic head (with bcd⁶)

(Shaw et al., 2002)

embryonic thorax (with bcd⁶)

(Shaw et al., 2002)

Detailed Description

Statement

Reference

Embryos derived from bcd⁶/bcd¹ females lack all head and thoracic structures and have a duplicated set of posterior spiracles at the anterior end.

(Shaw et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

bcd⁶/bcd¹ has embryonic/larval posterior spiracle | ectopic phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

bcd⁶/bcd¹ has embryonic thorax phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

bcd⁶/bcd¹ has embryonic head phenotype, suppressible | partially by Mdoa\bcd^bcd.1

(Shaw et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Mdoa\bcd^bcd.1 partially rescues the defects seen in embryos derived from bcd⁶/bcd¹ females, with the degree of rescue depending on the Mdoa\bcd^bcd.1 line used. In the strongest rescuing line, complete rescue is seen in a small proportion of embryos, as shown by the presence of all three thoracic segments, a complete head skeleton and other anterior structures such as the mouthhooks and labrum. 7.4% of embryos can develop into fully fertile adults, but most embryos show no rescue.

(Shaw et al., 2002)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Intermediate bcd allele.

(Driever and Nusslein-Volhard, 1988)

hb protein expression in early bcd¹ mutant embryos has been studied.

(Tautz, 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bcd⁰⁸⁵

(Riede, 2004, Shaw et al., 2002, Wolff et al., 1998, Bonneton et al., 1997, Dubnau and Struhl, 1996, Rivera-Pomar et al., 1996, Driever, 1993, Struhl et al., 1989, Berleth et al., 1988, Driever and Nusslein-Volhard, 1988, Tautz, 1988, Tearle and Nusslein-Volhard, 1987)

bcd¹

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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