FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bcdTN3
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General Information
Symbol
Dmel\bcdTN3
Species
D. melanogaster
Name
FlyBase ID
FBal0030600
Feature type
allele
Associated gene
Dmel\bcd
Associated Insertion(s)
Carried in Construct
P{bcdTN3}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Driever et al., 1990)
Progenitor genotype
Carried in construct
P{bcdTN3}
Cytology
Description

Construct: bcd 5' sequences are exchanged with Xenopus β-globin 5' nontranslated sequences.

(Driever et al., 1990)
Allele components
Component
Use(s)
Encoded product / tool
bcd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In vitro transcribed bcdTN3 mRNA can induce anterior development at any ectopic position along the anterior-posterior axis. Injection into the posterior pole of bcd6 embryos suppresses posterior development and induces the formation of head and thoracic structures at the posterior end. Injection into the middle of the embryo induces gnathal and thoracic structures at the site of injection.

      (Driever et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      bcdTN3 rescues bcd6

      (Driever et al., 1990)
      Comments

      One copy of P{bcdTN3} in bcd6 embryos expands and shifts the bcd expression domain slightly more anterior towards the gnathal and thoracic regions. Two copies rescues the bcd6 mutant phenotype completely.

      (Driever et al., 1990)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "bcdTN3" and in vitro transcribed in wheat germ and reticulocyte lysate systems for injection into bcd6 females to study rescue of the mutant phenotype.

      (Driever et al., 1990)

      Carried in plasmid "BcdTN3", protein expressed from the Sp6 promoter, radioactively labeled in a reticulocyte translation system and interaction with various bcd domains is assayed using coimmunoprecipitation analysis.

      (Yuan et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      bcdTN3
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0030598
      References (3)