FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tsl1
Open Close
General Information
Symbol
Dmel\tsl1
Species
D. melanogaster
Name
FlyBase ID
FBal0017195
Feature type
allele
Associated gene
Dmel\tsl
Associated Insertion(s)
Carried in Construct
Also Known As
tsl035, tslo35
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Savant-Bhonsale and Montell, 1993, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: V215M.

(Savant-Bhonsale and Montell, 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,778,771..21,778,771 [-]
Nucleotide change:

G21778771A

Amino acid change:

V215M | tsl-PA; V215M | tsl-PB; V215M | tsl-PC

Reported amino acid change:

V215M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Savant-Bhonsale and Montell, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Posterior defect is significantly suppressed, in a dose-dependent manner, by Dsor1Su1.

      (Tsuda et al., 1993)

      A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly.

      (Ambrosio et al., 1989)

      A single tor11D allele variably suppresses the phenotype caused by tsl1 in embryos derived from females homozygous for tsl1 and heterozygous for tor11D, depending on the temperature.

      (Casanova and Struhl, 1989)

      maternal-effect lethal Anterior- and posteriormost structures (labrum, dorsal bridge, telson, eighth and part of seventh abdominal segments) deleted in embryos produced by homozygous mothers. tsl pole cells transplanted into wild-type hosts produce normal progeny, whereas the reciprocal transplant produces tsl embryos.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of bcdΔA to tsl1, bcd6 embryos rescues the anterior part of the tsl1 mutant phenotype (rescuing the labrum and dorsal bridge) as well as rescuing the bcd6 mutant phenotype. This results in embryos with a posterior terminal mutant phenotype only.

      The addition of tsl1 does not effect the ability of bcdΔQAC to rescue the bcd6 phenotype. The addition of bcdΔA to tsl1, bcd6 embryos rescues the terminal system phenotype seen in these animals.

      (Schaeffer et al., 2000)

      Mutant phenotype of bcd, tsl double mutants is partially rescued by hbbcd.3UTR.

      (Schulz and Tautz, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series: tsl5 = tsl4 > tsl3 > tsl1 > tsl2

      (Savant-Bhonsale and Montell, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (18)