FB2026_03 , released September 17, 2026
Allele: Dmel\baboA.ΔI.UAS
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General Information
Symbol
Dmel\baboA.ΔI.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0155622
Feature type
allele
Associated gene
Dmel\babo
Associated Insertion(s)
Carried in Construct
P{UAS-babo.A.ΔI}
Key Links
Transgenic product class
dominant_negative_variant
(Parker et al., 2006)
Mutagen
    Nature of the Allele
    Transgenic product class
    dominant_negative_variant
    (Parker et al., 2006)
    Mutagen
    Progenitor genotype
    Carried in construct
    P{UAS-babo.A.ΔI}
    Cytology
    Description

    UAS sequences regulate expression of a dominant-negative form of the babo a isoform, which retains the ligand-binding domain but lacks the intracellular kinase domain.

    (Parker et al., 2006)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    UAS
    Encoded product / tool
    babo
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS together in motorneurons, driven by Scer\GAL4OK6, causes ISNb pathfinding defects and SNa branching defects. The more copies of baboA.ΔI.Scer\UAS that are expressed, the higher the penetrance of the phenotype. This phenotype also occurs when baboA.ΔI.Scer\UAS is expressed under the control of Scer\GAL4elav-C155.

        Expression of baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS together in muscle, driven by Scer\GAL4Mef2.PR, results in a low penetrance of weak ISNb defects and no SNa defects.

        When baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS are expressed together in glia, under the control of Scer\GAL4repo, only 4% of hemisegments show ISNb pathfinding defects and 2% show SNa branching defects.

        (Parker et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        baboA.ΔI.Scer\UAS
        baboA.ΔI.UAS
        Name Synonyms
        Secondary FlyBase IDs
          References (2)