FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\baboA.ΔI.UAS
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General Information
Symbol
Dmel\baboA.ΔI.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0155622
Feature type
allele
Associated gene
Dmel\babo
Associated Insertion(s)
Carried in Construct
P{UAS-babo.A.ΔI}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(McCabe et al., 2003)
Progenitor genotype
baboUAS.cBa
(McCabe et al., 2003)
Carried in construct
P{UAS-babo.A.ΔI}
Cytology
Description

The babo ORF of isoform A in baboUAS.cBa from which a BglII/Asp718 fragment has been removed and replaced by a linker containing stop sites and an SpeI restriction site.

(McCabe et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
babo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS together in motorneurons, driven by Scer\GAL4OK6, causes ISNb pathfinding defects and SNa branching defects. The more copies of baboA.ΔI.Scer\UAS that are expressed, the higher the penetrance of the phenotype. This phenotype also occurs when baboA.ΔI.Scer\UAS is expressed under the control of Scer\GAL4elav-C155.

      Expression of baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS together in muscle, driven by Scer\GAL4Mef2.PR, results in a low penetrance of weak ISNb defects and no SNa defects.

      When baboA.ΔI.Scer\UAS and baboB.ΔI.Scer\UAS are expressed together in glia, under the control of Scer\GAL4repo, only 4% of hemisegments show ISNb pathfinding defects and 2% show SNa branching defects.

      (Parker et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "UAST-baboAΔI", and expressed in S2 cells.

      (McCabe et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      baboA.ΔI.Scer\UAS
      baboA.ΔI.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)